Betaine Supplementation Decreases Plasma Homocysteine Concentrations But Does Not Affect Body Weight, Body Composition, Or Resting Energy Expenditure In Human Subjects

Effect None
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 42
Sex Both Genders
Age Range 18-29, 30-44
Body Types Obese
Notes for this study:
In obese subjects given supplementation of betaine at 6g daily for 12 weeks was able to decrease homocysteine (9%) relative to placebo but the decrease in total cholesterol and LDL seen in placebo was not present in betaine intervention; there was no influence on body weight. There was no influence on plasma nor RBC folate concentrations.

The increase in ALP (liver enzyme) seen in placebo was prevented with betaine.