| Effect | None |
| Trial Design | Double blind |
| Trial Length | 6+ Months |
| Number of Subjects | 42 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44 |
| Body Types | Obese |
In obese subjects given supplementation of betaine at 6g daily for 12 weeks was able to decrease homocysteine (9%) relative to placebo but the decrease in total cholesterol and LDL seen in placebo was not present in betaine intervention; there was no influence on body weight. There was no influence on plasma nor RBC folate concentrations.
The increase in ALP (liver enzyme) seen in placebo was prevented with betaine.
