Studies related to Serum Methionine and Trimethylglycine

Low Dose Betaine Supplementation Leads to Immediate and Long Term Lowering of Plasma Homocysteine in Healthy Men and Women
Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 76
Sex Both Genders
Age Range 18-29, 30-44
Notes for this study:
In otherwise healthy humans given 1,500-6,000mg of betaine supplementation daily either acutely or over six weeks, the levels of homocysteine in plasma appear to be reduced with similar potency after a single dose and after six weeks in a dose-dependent manner (12-20%) and the increase in homocysteine after a methionine load is also reduced (16-35%); methoinine in plasma was increased after six weeks with the highest dose only by 60% (fasted state) and 12% (post methionine load).

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