Studies related to and

Androgens And Sexual Function: A Placebo-controlled, Randomized, Double-blind Study Of Testosterone Vs. Dehydroepiandrosterone In Men With Sexual Dysfunction And Androgen Deficiency

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 79
Gender Male
Age Range 45-64, 65+
Body Types Overweight
Notes for this study:
DHEA, at 100mg daily in older (average age of 60) men with sexual dysfunction over 16 weeks failed to significantly increase testosterone (despite increasing DHEA and DHEAS) and subsequently failed to improve the state of sexual dysfunction the participants were in.

Effect Of Acute DHEA Administration On Free Testosterone In Middle-aged And Young Men Following High-intensity Interval Training

Effect None
Trial Design Double blind
Trial Length 24 hours
Number of Subjects 16
Gender Male
Age Range 18-29, 45-64
Body Types Average
Notes for this study:
Acute supplementation of 50mg DHEA prior to exercise is able to promote levels of free testosterone independent of changes in testosterone in middle aged men and prevent a decline of free testosterone during exercise.

Effects Of Short-term Dehydroepiandrosterone Supplementation On Body Composition In Young Athletes

Effect Increase
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 20
Gender Male
Age Range 18-29
Body Types Trained, Average
Notes for this study:
Young male athletes (19-22) were given DHEA at 100mg for 28 days and resulted in increased testosterone and estrogen levels, but did not influence parameters of fat mass or lean mass.

Subjects were soccer players and no mention was made of resistance training.

Effect Of Oral DHEA On Serum Testosterone And Adaptations To Resistance Training In Young Men

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 19
Gender Male
Age Range 18-29
Body Types Untrained, Average
Notes for this study:
DHEA supplementation at 50mg did not influence testosterone levels acutely (despite an increase in androstenedione) and 150mg of DHEA was unable to influence testosterone levels over 6 weeks in young healthy men.

No significant differences were seen in placebo versus DHEA at 150mg in regards to strength gain and lean mass accrual.

Effects Of Dehydroepiandrosterone Supplementation On Cognitive Function And Activities Of Daily Living In Older Women With Mild To Moderate Cognitive Impairment

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 27
Gender Female
Age Range 65+
Body Types Average
Notes for this study:
27 older frail women given DHEA over 6 months improved at cognitive parameters such as verbal fluency while the control group deteriorated.

Long-term Low-dose Dehydroepiandrosterone Oral Supplementation In Early And Late Postmenopausal Women Modulates Endocrine Parameters And Synthesis Of Neuroactive Steroids

Effect Increase
Trial Design Cohort
Trial Length 6+ Months
Number of Subjects 20
Gender Female
Age Range 45-64
Body Types Overweight
Notes for this study:
25mg of DHEA over 12 months was able to increase all steroid hormones in the serum, including the neurosteroids allopregnanolone and beta-endorphin. SHBG also decreased alongside cortisol, and overall menopausal symptoms in these women was decreased.

Effects Of Dehydroepiandrosterone Vs Androstenedione Supplementation In Men

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 40
Gender Male
Age Range 30-44
Body Types Trained, Average
Notes for this study:
100mg of DHEA for 12 weeks in previously weight trained middle aged men was unable to increase lean mass more than placebo, but was not associated with any adverse biochemicular effects.

Dehydroepiandrosterone Combined With Exercise Improves Muscle Strength And Physical Function In Frail Older Women

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 99
Gender Female
Age Range 65+
Body Types Overweight
Notes for this study:
50mg of DHEA given daily for 6 months to older frail women*was unable to significantly affect bone mineral density over 6 months yet increased serum steroid status (testosterone, estrogen, DHEA) and increased lower body strength and functionality when DHEA was used in conjunction with non-strenuous exercises.

Long-term Low-dose Oral Administration Of Dehydroepiandrosterone Modulates Adrenal Response To Adrenocorticotropic Hormone In Early And Late Postmenopausal Women

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 20
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
Circulating steroids increased after low dose (25mg) DHEA administration for up to a year, yet after 3 months of supplementation cortisol appeared to decline and the adrenal glands released less cortiol in response to ACTH hormone stimulation; suggesting a modification of the stress response. 17-hydroxyprogresterone only increased during months 6-12, not month 3.

Subjects were otherwise healthy menopausal women aged 50-65/

Lack Of Dehydroepiandrosterone Effect On A Combined Endurance And Resistance Exercise Program In Postmenopausal Women

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 31
Gender Female
Age Range 45-64, 65+
Body Types Untrained, Overweight
Notes for this study:
50mg of DHEA over 12 weeks in healthy postmenopausal women with an average age of 64.6yrs and who were sedentary at the start of the study.

With the introduction of exercise, beneficial changes in body composition were due to exercise and there was no difference in the DHEA group relative to placebo.

A reduction in small dense LDL particles (oxidized LDL usually) was noted.
Funding issues for this study:
NIH grant, likely a nonissue

Six-month Oral Dehydroepiandrosterone Supplementation In Early And Late Postmenopause

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 36
Gender Female
Age Range 45-64
Body Types Overweight, Average
Notes for this study:
50mg of DHEA over 6 months in menopausal women showed that testosterone and estrogen increased, while SHBG decreased only in overweight women significantly. Plasma levels of neurosteroids (beta-endorphin and allopregnanolone) increased while cortisol and gonadotropins decreased.

SHBG decreased only in the subset of postmenopausal women who were older and overweight.

Dehydroepiandrosterone Replacement In Healthy Men With Age-related Decline Of DHEA-S: Effects On Fat Distribution, Insulin Sensitivity And Lipid Metabolism

Effect None
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 12
Gender Male
Age Range 45-64
Body Types Overweight
Notes for this study:
50mg of DHEA given for 3 months in a double blind manner to aged men with low circulating DHEA levels but otherwise healthy status was unable to significantly influence any study parameter despite increasing circulating DHEA levels. The only effect that was notable was an increasing trend to increase LDL and Triglycerides, which did not reach statistical significance.

Effects Of Dehydroepiandrosterone And Atamestane Supplementation On Frailty In Elderly Men

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 83
Gender Male
Age Range 65+
Body Types Overweight
Notes for this study:
DHEA, either alone at 50mg daily or in combination with an aromatase inhibitor (atamestane at 100mg) was studied for 36 weeks in otherwise healthy an non-hospitalized older men with low scores on physical strength (frailty).

Testosterone increased in all groups, with the DHEA+AI group increasing more than double that of DHEA or AI alone (8.5, 3.5, 4.9nmol/L respectively), DHEA+AI had about 1.3rd the increase in estrogen seen in DHEA, while AI saw a decrease relative to placebo. IGF-1 increased in all groups, but only significantly in the combination. The combination seemed to improve body composition, but was statistically insignificant.

Cognitive decline was measured via MMSE but showed no influence with DHEA, and the changes in IGF binding proteins were too variable to be significant (although an interaction seemed to be present)

Supplementation With DHEA: Effect On Muscle Size, Strength, Quality Of Life, And Lipids

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 50
Gender Female
Age Range 45-64, 65+
Notes for this study:
DHEA at 50mg daily in menopausal women does not influence muscle mass, libido, sleep quality or well being despite increasing circulating androgen status. Estrone and SHBG were unaffected alongside cortisol. Functional tests failed to show a protective effect of either DHEA or estrogen replacement therapy (active control) and power output (knee flexion) was unaffected. Cholesterol decreased 8%.

Dehydroepiandrosterone Replacement Therapy In Older Adults: 1- And 2-y Effects On Bone

Effect Increase
Trial Design Double blind
Trial Length 6+ Months
Number of Subjects 113
Gender Both Genders
Age Range 65+
Body Types Overweight
Notes for this study:
*Confounded with low dose [Vitamin D] and high-dose calcium [Calcium], although placebo group took those supplements as well and thus it is unlikely to influence final results*

Over 2 years of supplementation at 50mg daily in older individuals, testosterone estrogen and IGF-1 increase in groups consuming DHEA.

Bone mineral density increased in women, but not men.

Short-term Dehydroepiandrosterone Treatment Increases Platelet CGMP Production In Elderly Male Subjects

Effect Increase
Trial Design Double blind
Trial Length 1-6 months
Number of Subjects 24
Gender Male
Age Range 45-64, 65+
Body Types Overweight, Average
Notes for this study:
2 months of DHEA supplements, 50mg at bedtime, was able to increase circulating levels of Platelet cyclic guanosine-monophosphate, a biomarker for Nitric Oxide.

It increased testosterone and estrogen, as well as plasminogen activating factor-1. Interestingly, DHEA also lowered LDL. Other biomarkers measured were not significantly affected.

Effects Of Dehydroepiandrosterone (DHEA) Supplementation On Hormonal, Metabolic And Behavioral Status In Patients With Hypoadrenalism

Effect None
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 20
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
DHEA at 50mg for 4 months was unable to influence serum testosterone levels in men, while it increased testosterone levels only in women with low circulating androgens. SHBG dropped in men and women, and DHEA-S in serum increased in both groups.

No effects on carbohydate metabolism or insulin sensitivity were seen. Fat mass decreased, no effects on well being and quality of life were seen.

Patients were hypoadrenics.

Effects Of Dehydroepiandrosterone (DHEA) Supplementation On Hormonal, Metabolic And Behavioral Status In Patients With Hypoadrenalism

Effect Increase
Trial Design Cohort
Trial Length 1-6 months
Number of Subjects 20
Gender Both Genders
Age Range 30-44, 45-64
Body Types Overweight
Notes for this study:
DHEA at 50mg for 4 months was unable to influence serum testosterone levels in men, while it increased testosterone levels only in women with low circulating androgens. SHBG dropped in men and women, and DHEA-S in serum increased in both groups.

No effects on carbohydate metabolism or insulin sensitivity were seen. Fat mass decreased, no effects on well being and quality of life were seen.

Patients were hypoadrenics.