Studies related to TNF-Alpha and Boron

The Adjuvant Use Of Calcium Fructoborate And Borax With Etanercept In Patients With Rheumatoid Arthritis: Pilot Study

Effect Decrease
Values Mean and SD. Placebo: before 195.9 (60), after 194.7 (7.7). Sodium tetraborate: before 177.1 (44.4), after 141.6 (38.6). Calcium fructoborate: before 152.4 (20.6), after 99.0 (38.2).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 80
Sex Both Genders
Notes for this study:
In a randomized, double-blind, placebo-controlled trial 80 participants with rheumatoid arthritis were allocated to take 220 mg of calcium fructoborate, 55 mg of sodium tetraborate, both containing 6 mg of elemental boron, or placebo for 8 weeks. Participants were all taking etanercept. Tenderness and swollenness of joints, as well as pain on a visual analog scale and evaluator's global assessment (EGA) were reduced more in the boron groups than the placebo group, without statistically significant differences between them.

Erythrocyte sedimention rate, c-reactive protein, IL-1a, and IL-6 were all notably decreased more by boron than placebo.