Studies related to Interleukin 6 and Boron

The Adjuvant Use Of Calcium Fructoborate And Borax With Etanercept In Patients With Rheumatoid Arthritis: Pilot Study

Effect Decrease
Values (pg/ml). Mean and SD. Placebo: before 13.6 (2.8), after 13.1 (3.1). Sodium tetraborate: before 17.3 (8.0), after 13.0 (4.8). Calcium fructoborate: before 18.7 (10.9), after 10.7 (4.7).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 80
Sex Both Genders
Notes for this study:
In a randomized, double-blind, placebo-controlled trial 80 participants with rheumatoid arthritis were allocated to take 220 mg of calcium fructoborate, 55 mg of sodium tetraborate, both containing 6 mg of elemental boron, or placebo for 8 weeks. Participants were all taking etanercept. Tenderness and swollenness of joints, as well as pain on a visual analog scale and evaluator's global assessment (EGA) were reduced more in the boron groups than the placebo group, without statistically significant differences between them.

Erythrocyte sedimention rate, c-reactive protein, IL-1a, and IL-6 were all notably decreased more by boron than placebo.

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