Effects Of Rhodiola Rosea Supplementation On Mental Performance, Physical Capacity, And Oxidative Stress Biomarkers In Healthy Men

Effect Increase
Values (U/gHb). Superoxide dismutase. Mean and SD. Placebo: At rest, before 1143.1 ± 60.9, after 1000.4 ± 147.1. Post exercise: before 1395.4 ± 90.8, after 1140.9 ± 79.9. 24H: before 1231.8 ± 95.8, after 988.9 ± 107.5. Rhodiola: At rest, before 1132.1 ± 91.1, after 1007.5 ± 80.2. Post exercise: before 1225.0 ± 70.5, after 1201.6 ± 98.4. 24H: before 1266.0 ± 90.5, after 1217.9 ± 60.6.
Trial Design Randomized trial
Trial Length 2-4 Weeks
Number of Subjects 26
Sex Male
Notes for this study:
In a randomized, double-blind, placebo-controlled trial, 26 healthy participants were allocated to take 600 mg of a Rhodiola Rosea extract (3% rosavins) or placebo daily for 4 weeks.

Simple reaction time improved somewhat when taking Rhodiola, though the difference wasn't statistically significant compared with placebo, and accuracy for choice reaction was also nonsignificantly improved. Blood lactate was reduced significantly at rest and nonsignificantly at max during an exercise trial (cycle ergometer). Heart rate was unaffected. There was a small, nonsignificant improvement in power and time to exhaustion, while VO2peak was unaffected.

Compared with placebo, there were no statistically significant differences in the change for cortisol, testosterone, growth hormone, creatine kinase, lipid hydroperoxides, superoxide dismutase, and total antioxidant capacity, though total antioxidant capacity was nonsignificantly increased, and cortisol after exercise was nonsignificantly decreased.