| Effect | Increase |
| Trial Design | Cohort |
| Trial Length | 1-6 months |
| Number of Subjects | 28 |
| Sex | Both Genders |
| Age Range | 45-64, 65+ |
In patients with probable/definite Amyotrophic Lateral Sclerosis (ALS), creatine monohydrate enhanced Maximal Voluntary Isometric Contraction (MVIC) significantly at the elbow (53% of subjects) and knee (70% of subjects) after the 1-week loading phase (20 g/day). However, over the 6-month maintenance phase (3 g/day), the rates of decline for both the upper and lower limbs were not statistically different from the rates of decline before treatment, suggesting no longer-term effect.
The study saw many dropouts due to initial diarrhea from the loading phase, but no abnormalities were detected in the kidney or the liver.
