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Effects Of Creatine Supplementation On Exercise Performance And Muscular Strength In Amyotrophic Lateral Sclerosis: Preliminary Results

Effect Increase
Trial Design Non-controlled trial
Trial Length 1-6 months
Number of Subjects 28
Sex Both Genders
Age Range 45-64, 65+
Notes for this study:
In patients with probable/definite Amyotrophic Lateral Sclerosis (ALS), creatine monohydrate enhanced Maximal Voluntary Isometric Contraction (MVIC) significantly at the elbow (53% of subjects) and knee (70% of subjects) after the 1-week loading phase (20 g/day). However, over the 6-month maintenance phase (3 g/day), the rates of decline for both the upper and lower limbs were not statistically different from the rates of decline before treatment, suggesting no longer-term effect.

The study saw many dropouts due to initial diarrhea from the loading phase, but no abnormalities were detected in the kidney or the liver.

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