Studies related to and

Creatine Supplementation Enhances Muscle Force Recovery After Eccentrically-induced Muscle Damage In Healthy Individuals

Effect None
Trial Design Double blind
Trial Length 2-4 Weeks
Number of Subjects 14
Gender Male
Age Range 18-29
Body Types Untrained, Average
Notes for this study:
Markers of acute muscle damage decreased.

Improvements in rate of recovery.

Standard loading protocol of 0.03g/kg bodyweight for 5 days (around 21g) and a lower maintenance period (around 5g)

Effects Of Creatine Supplementation On Oxidative Stress And Inflammatory Markers After Repeated-sprint Exercise In Humans

Effect Decrease
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 25
Gender Male
Age Range 13-17, 18-29
Body Types Trained, Average
Notes for this study:
In youth, 300 mg/kg/day for 1 week was able to improve performance on a repeated sprint test (35-m sprints, repeated six times with 10-s rests) relative to placebo, but this was not associated with any change in fatigue (assessed via fatigue index) or in biomarkers of oxidative stress, although inflammation was attenuated.

There were unclear effects on muscle damage, since creatine kinase increased while LDH (lactate dehydrogenase, a liver enzyme) decreased.

Effects Of Creatine Supplementation On Oxidative Stress And Inflammatory Markers After Repeated-sprint Exercise In Humans

Effect Increase
Trial Design Double blind
Trial Length 1-7 Days
Number of Subjects 25
Gender Male
Age Range 13-17, 18-29
Body Types Trained, Average
Notes for this study:
In youth, 300 mg/kg/day for 1 week was able to improve performance on a repeated sprint test (35-m sprints, repeated six times with 10-s rests) relative to placebo, but this was not associated with any change in fatigue (assessed via fatigue index) or in biomarkers of oxidative stress, although inflammation was attenuated.

There were unclear effects on muscle damage, since creatine kinase increased while LDH (lactate dehydrogenase, a liver enzyme) decreased.

Effect Of Short-term Creatine Supplementation On Markers Of Skeletal Muscle Damage After Strenuous Contractile Activity

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 8
Gender n/a
Notes for this study:
Conducted in IronMan athletes.

Confounded with Maltodextrin.

The Effect Of Creatine Supplementation Upon Inflammatory And Muscle Soreness Markers After A 30km Race

Effect Decrease
Trial Design Double blind
Trial Length n/a
Number of Subjects 34
Gender n/a
Notes for this study:
Study conducted in seasoned runners with a personal best in the 2.5-3 hour marathon range, tested after running 30km.

Dosed at 20g creatine per day with 60g maltodextrin (4 doses of 5g creatine monohydrate with 15g carbohydrate) for 5 days prior to event.

Creatine attenuated increases in creatine kinase, PGE2, and TNF-Alpha while abolishing increases in lactate dehydrogenase.

No significant difference noted between groups in marathon time to completion.

Creatine Supplementation Does Not Reduce Muscle Damage Or Enhance Recovery From Resistance Exercise

Effect None
Trial Design Double blind
Trial Length n/a
Number of Subjects 22
Gender n/a
Notes for this study:
Testing protocol was 15-20 rep squats, 5 sets at 50% 1RM.

Parameters measured indicated that creatine supplementation did not alleviate damage nor enhance recovery from exercise.