Studies related to Arterial Stiffness and Citrulline

Does L-citrulline Supplementation Improve Exercise Blood Flow In Older Adults?

Effect None
Values Mean and SD. Carotid-femoral pulse wave velocity (m/s). Women: Placebo: before 8.9 ± 1.5, after 9.1 ± 1.7. Citrulline: before 9.0 ± 1.5, after 9.0 ± 1.4. Men: Placebo: before 8.8 ± 1.2, after 8.8 ± 1.0. Citrulline: before 8.7 ± 1.2, after 8.8 ± 1.2.
Trial Design Randomized trial
Trial Length 1-2 Weeks
Number of Subjects 25
Sex Both Genders
Age Range 45-64, 65+
Notes for this study:
In this randomized, double-blind, placebo-controlled crossover study, 25 healthy participants aged 61-80 took 6 g (3 g twice daily) of citrulline or placebo for 2 weeks each with a 2-week washout period in between.

Blood flow during exercise increased only for men while taking citrulline during exercise. Diastolic, but not systolic blood pressure was statistically significantly reduced for both sexes at rest, while plasma nitric oxide and carotid-femoral pulse wave velocity weren't statistically significantly different.

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