| Effect | Increase |
| Values | 6 minute walking time. Mean and 95% CI. Change from baseline. −44.1 (−73.2 to −15.1) |
| Trial Design | Non-controlled trial |
| Trial Length | 1-2 Weeks |
| Number of Subjects | 25 |
| Sex | Both Genders |
In this randomized, uncontrolled trial, 25 participants with pulmonary hypertension were given 3 g of citrulline malate daily for 2 weeks.
The primary outcome was the change in exercise capacity, and there was a statistically significant improvement in 6 minute walking distance. There was also an improvement in pulmonary arterial pressure, and quality of life.
