Studies related to Exercise Capacity and Citrulline

Oral L-citrulline Malate In Patients With Idiopathic Pulmonary Arterial Hypertension And Eisenmenger Syndrome: A Clinical Trial

Effect Increase
Values 6 minute walking time. Mean and 95% CI. Change from baseline. −44.1 (−73.2 to −15.1)
Trial Design Non-controlled trial
Trial Length 1-2 Weeks
Number of Subjects 25
Sex Both Genders
Notes for this study:
In this randomized, uncontrolled trial, 25 participants with pulmonary hypertension were given 3 g of citrulline malate daily for 2 weeks.

The primary outcome was the change in exercise capacity, and there was a statistically significant improvement in 6 minute walking distance. There was also an improvement in pulmonary arterial pressure, and quality of life.