Studies related to Liver Fat and Citrulline

Inflammatory Markers Response To Citrulline Supplementation In Patients With Non-alcoholic Fatty Liver Disease: A Randomized, Double Blind, Placebo-controlled, Clinical Trial

Effect None
Values Steatosis grade (0/1/2/3) Mean and SD. Placebo: before 2.62 ± 0.66, after 2.38 ± 0.88. Citrulline: before 2.86 ± 0.35, after 2.44 ± 0.85 . Steatosis (dB/m ). Placebo: before 315.5 ± 36.8, after 299.6 ± 45.7. Citrulline: before 320.8 ± 29.6, after 304.5 ± 39.1.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 50
Sex Both Genders
Notes for this study:
In this randomized, double-blind, placebo-controlled trial, 50 patients with NAFLD took 2 g of l-citrulline or placebo daily for 3 months.

83% of participants completed the study. There was a notably greater, statistically significant reduction in c-reactive protein and Nf-kb in the citrulline group compared with the placebo group, though there wasn't a notable difference for TNF-a. However, this didn't coincide with a notable difference in fibrosis or steatosis.