Oxidative Stress And Nitrate/nitrite (NOx) Status Following Citrulline Supplementation In Type 2 Diabetes: A Randomised, Double-blind, Placebo-controlled Trial

Effect Increase
Values Total antioxidant capacity. mmol/l. Mean and SD. Placebo: before 1.33 (0.19), after 1.26 (0.17). Citrulline: before 1.33 (0.22), after 1.54 (0.18).
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 54
Sex Both Genders
Notes for this study:
In this randomized, double-blind, placebo-controlled trial, 54 patients with type 2 diabetes took 3 g of l-citrulline daily for 2 months.

83.3% of participants completed the trial. There was a notably greater reduction in fasting blood sugar in the citrulline group than the placebo group, a difference that was statistically significant. There was also a greater reduction in malondialdehyde, a greater increase in total antioxidant capacity, nitric oxide, glutathione peroxidase, and citrulline, while there wasn't a statistically significant difference for superoxide dismutase.