Studies related to Oxygen Uptake and Citrulline

Impact Of L-citrulline Supplementation On Oxygen Uptake Kinetics During Walking

Effect Both
Values Change. Mean and SE.  Net VO2 (mL/kg/min. Placebo: Young: −0.73 ± 0.39 Older: −0.57 ± 0.45 Women: −0.41 ± 0.38 Men: −0.89 ± 0.46 Citrulline. Young: −0.73 ± 0.39 Older: −0.01 ± 0.45 Women: −0.16 ± 0.38 Men: −0.58 ± 0.46. Mean response time.(s). Placebo: Young: 3.80 ± 1.83 Older: 2.59 ± 2.15 Women: 2.93 ± 1.81 Men: 3.46 ± 2.17 Citrulline. Young: −1.79 ± 1.83 Older: −0.50 ± 2.15 Women: 2.26 ± 1.81 Men: −4.54 ± 2.17. 95% confidence interval for rate constant. (s). Placebo: Young: −0.46 ± 0.66 Older: −0.60 ± 0.78 Women: −0.74 ± 0.66 Men: −0.32 ± 0.79 Citrulline. Young: 0.54 ± 0.66 Older: 0.59 ± 0.78 Women: 0.76 ± 0.66 Men: 0.38 ± 0.79. O2 deficit (L). Placebo: Young: 0.01 ± 0.04 Older: −0.01 ± 0.05 Women: 0.01 ± 0.04 Men: 0.01 ± 0.05 Citrulline. Young: −0.10 ± 0.04 Older: −0.05 ± 0.05 Women: 0.01 ± 0.04 Men: −0.15 ± 0.05
Trial Design Randomized trial
Trial Length 1-7 Days
Number of Subjects 26
Sex Both Genders
Age Range 18-29, 30-44, 45-64, 65+
Notes for this study:
In this randomized, double-blind, placebo-controlled crossover trial, 26 healthy participants took 6 g of citrulline or placebo for 7 days each.

The primary outcome was VO2 kinetics during submaximal exercise. Net Vo2 wasn't statistically significantly different for any demographic group, whether it be men, women, older, or younger, and the same was the case for 95% confidence interval for rate constant. Mean response time was significantly reduced for young but not older and men but not women. O2 deficit was significantly reduced for young but not older and men but not women.