Impact Of L-citrulline Supplementation On Oxygen Uptake Kinetics During Walking
| Effect | Both |
| Values | Change. Mean and SE. Net VO2 (mL/kg/min. Placebo: Young: −0.73 ± 0.39 Older: −0.57 ± 0.45 Women: −0.41 ± 0.38 Men: −0.89 ± 0.46 Citrulline. Young: −0.73 ± 0.39 Older: −0.01 ± 0.45 Women: −0.16 ± 0.38 Men: −0.58 ± 0.46. Mean response time.(s). Placebo: Young: 3.80 ± 1.83 Older: 2.59 ± 2.15 Women: 2.93 ± 1.81 Men: 3.46 ± 2.17 Citrulline. Young: −1.79 ± 1.83 Older: −0.50 ± 2.15 Women: 2.26 ± 1.81 Men: −4.54 ± 2.17. 95% confidence interval for rate constant. (s). Placebo: Young: −0.46 ± 0.66 Older: −0.60 ± 0.78 Women: −0.74 ± 0.66 Men: −0.32 ± 0.79 Citrulline. Young: 0.54 ± 0.66 Older: 0.59 ± 0.78 Women: 0.76 ± 0.66 Men: 0.38 ± 0.79. O2 deficit (L). Placebo: Young: 0.01 ± 0.04 Older: −0.01 ± 0.05 Women: 0.01 ± 0.04 Men: 0.01 ± 0.05 Citrulline. Young: −0.10 ± 0.04 Older: −0.05 ± 0.05 Women: 0.01 ± 0.04 Men: −0.15 ± 0.05 |
| Trial Design | Randomized trial |
| Trial Length | 1-7 Days |
| Number of Subjects | 26 |
| Sex | Both Genders |
| Age Range | 18-29, 30-44, 45-64, 65+ |
In this randomized, double-blind, placebo-controlled crossover trial, 26 healthy participants took 6 g of citrulline or placebo for 7 days each.
The primary outcome was VO2 kinetics during submaximal exercise. Net Vo2 wasn't statistically significantly different for any demographic group, whether it be men, women, older, or younger, and the same was the case for 95% confidence interval for rate constant. Mean response time was significantly reduced for young but not older and men but not women. O2 deficit was significantly reduced for young but not older and men but not women.
