Studies related to NF-kB Activity and Citrulline

Inflammatory Markers Response To Citrulline Supplementation In Patients With Non-alcoholic Fatty Liver Disease: A Randomized, Double Blind, Placebo-controlled, Clinical Trial

Effect Decrease
Values (ng/mg protein) Mean and SD. Placebo: before 1.99 ± 1.34, after 2.64 ± 0.72. Citrulline: before 2.46 ± 0.72, after 2.11 ± 0.42.
Trial Design Randomized trial
Trial Length 1-6 months
Number of Subjects 50
Sex Both Genders
Notes for this study:
In this randomized, double-blind, placebo-controlled trial, 50 patients with NAFLD took 2 g of l-citrulline or placebo daily for 3 months.

83% of participants completed the study. There was a notably greater, statistically significant reduction in c-reactive protein and Nf-kb in the citrulline group compared with the placebo group, though there wasn't a notable difference for TNF-a. However, this didn't coincide with a notable difference in fibrosis or steatosis.