Various Erectogenic Agents (aka Boner Pills). And Yohimbine.

A plethora of updates on male sexuality. And yohimbine too.

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A large amount of updates this week. In our attempts to get any supplement referred to as a Testosterone Booster, we branched out into the related fields of erectogenesis agents and Aphrodisiac compounds; this week consists of Yohimbine and a large amount of minor updates in these latter two categories.

Firstly, Damiana Leaf is pretty useless. Limited evidence and the preliminary evidence does not suggest anything potent at all.

Asparagus racemosus (not the commonly consumed vegetable) appears to have putative build-up effects on aphrodisia and erectogenesis like Maca does, but no human studies exist. In these studies, Asparagus R is always outperformed by other compounds and appears weak. It is healthy regardless and may be adaptogenic a tad, but nothing remarkable exists.

Chlorophytum borivilianum (Safed Musli) is the compound that continually outperformed Asparagus. It appears to be quite effective as a boner pill and a bit more-so as an aphrodisiac; still no human studies (of quality, two confounded with funding from USPLabs and with Mucuna pruriens). One preliminary study on macrophages suggests potent interactions with releasing Nitric Oxide, but these need to be replicated.

Pycnogenol is similar to Grape Seed Extract in the sense that it is a source of procyanidin compounds that enhance blood flow. Doses of 100-200mg over a period of time appear to be effective in increasing blood flow secondary to Nitric Oxide, and although it doesn't appear to induce erectogenesis per se it serves a role in attenuating the effects of erectile dysfunction.

Muira puama is a short update, but preliminary effects suggest very potent adaptogenic effects in preventing chronic stress induced anxiety and performance reductions. The human studies currently are subpar and not catered to assess these effects though, and despite traditional claims of it being an aphrodisiac and vitality enhancer there is no solid evidence for these claims. Muira Puama may be more of a herb that is used in states of abnormal body function (unhealthy states) rather than one that brings a healthy person above and beyond. Also appears to be a potent cognitive booster via Cholinergic means.

Aronia melanocarpa is completely irrelevant to all the above. It is basically a denser blueberry. Can make unhealthy people a bit healthier while not being shown to exert any benefit in healthy people; the juice can be used rather than a supplement.

Yohimbine is the major update. In regards to sexuality it appears to have aphrodisiac and pro-erectile effects, but its potency in helping erectile dysfunction appears to be quite weak. It may serve a role in psychogenic erectile dysfunction or social anxiety due to reducing inhibitions (note: effects on anxiety per se are more pro-anxiety than anything, although this is mediated via noradrenaline rather than A2A antagonism like the former is).

Yohimbine reliably increases noradrenaline levels in the body, which underlies the side-effects of anxiety and hypertension; these effects appear to be subject to a large amount of individual differences, so using yohimbine should involve low doses working upwards.

It is a potent fat burning compound in the human studies that 'met the conditions' of it, and yohimbine appears to be dependent on exercise and/or a fasted state. It showed lots of promise in one study on soccer players at an elite level (lots of exercise), yet some studies in sedentary women and men without exercise fail to note any effect even at the higher end of doses. This appears to be a thin person's fat loss agent.


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