This week features three updates and a lot of behind-the-scene work to bring you more substantial updates next week.
The two test boosters mentioned in the title are Bryonia Laciniosa and Massularia Acuminata. Both have been shown to boost test in limited animal studies, and Massularia appears to be a potent aphrodisiac. Byronia has not yet been implicated in toxicity, Massularia has in high doses; still not to the possible degree of Bulbine Natalensis (the most promising herbal test booster with associated harm to it). No human studies on either Massularia nor Byronia, so conclusions are hard to draw.
The tongue twister is PQQ, or Pyrroloquinoline Quinone. It is this week's major update.
Mechanistically, it is basically a CoQ10 molecule that floats around in the cell's cytoplasm and associates with protein structures rather than embedding itself in the electron transport chain. It has been shown to induce mitochondrial biogenesis in rat studies, and is a vitamin-like compound in nature (does not have vitamin status due to having no enzyme dependent on it and having no true deficiency state)
Two human studies have apparently been conducted, as the more promising one is unable to be sourced at this moment in time. The one cited in the rubric includes improved sleep patterns with 20mg PQQ in persons with sleep disorders; some limitations to this study though, as it was open-label and not the highest quality.
When looking collectively at the in vitro and animal studies though, PQQ appears to be almost a panacea. Some limited toxicological evidence suggests it might have less of a therapeutic threshold that is advised (with increasing efficacy, comes increasing side-efficacy) as kidney inflammation is seen at 11-12mg/kg in rats (based on rudimentary body weight conversions, this is 1.76-1.92mg/kg, or 120-131mg daily for a 150lb person) and if one is to supplement with PQQ on faith it would be prudent to not superload it.