Quick note

Confused about supplements?

Free 5 day supplement course




I mentioned a long time ago about mTOR, the signalling pathway in cells causative of muscle protein synthesis.

I also mentioned a few weeks back about AMPK, a signalling pathway that increases nutrient uptake into cells.

Although they sound like a great pair, they really don't like each other.[1] Not one bit. In fact, if you activate mTOR, then AMPK tends to become immediately suppressed[2] and if you activate AMPK, then mTOR tends to becomes suppressed.[3]

For these reasons, it would probably be good to avoid activating AMPK excessively near a workout if the goal is muscle mass accrual and to avoid activating mTOR needlessly if your goal is fat loss (although Leucine can be good for preserving lean mass; use it only if needed)


Published By on

Want to know how to look past the headlines and get the real facts on research?

Here's your guide to knowing how research is abused and how to be better at discerning it

Your e-mail is safe with us. We don’t share personal data.