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PRL-8-53, a synthetic nootropic compound, has been examined and added to the database. PRL-8-53 is taken for its ability to boost short term memory, though it does not have a lot of evidence for its effects.
PRL-8-53 was created by Nikolaus R. Hansl while he was studying a class of molecules called benzoates. Giving PRL-8-53 to rats showed very promising memory-enhancing effects. In 1978, a human study was conducted. It involved PRL-8-53 supplementation and a subsequent memory test. People that initially scored low on the test benefitted greatly from supplementation, while high performers did not see improvement. PRL-8-53 was compared to nootropics like piracetam, which helps people with poor memory, while having no effect on people with a good memory.
Unfortunately, no additional evidence has been published since that study. Though there is no data to disprove PRL-8-53’s effects, the benefits noted in the lone human study have not been replicated independently.
PRL-8-53 cannot be recommended as a dietary supplement because of the unexplained drop off in research, and because the original studies were funded by the patent holder and have not been replicated.
Published By Kamal Patel on 2014-03-04 11:44:32