Written by Kamal Patel
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PRL-8-53, a synthetic nootropic compound, has been examined and added to the database. PRL-8-53 is taken for its ability to boost short term memory, though it does not have a lot of evidence for its effects.

PRL-8-53 was created by Nikolaus R. Hansl while he was studying a class of molecules called benzoates. Giving PRL-8-53 to rats showed very promising memory-enhancing effects. In 1978, a human study was conducted. It involved PRL-8-53 supplementation and a subsequent memory test. People that initially scored low on the test benefitted greatly from supplementation, while high performers did not see improvement. PRL-8-53 was compared to nootropics like piracetam, which helps people with poor memory, while having no effect on people with a good memory.

Unfortunately, no additional evidence has been published since that study. Though there is no data to disprove PRL-8-53’s effects, the benefits noted in the lone human study have not been replicated independently.

PRL-8-53 cannot be recommended as a dietary supplement because of the unexplained drop off in research, and because the original studies were funded by the patent holder and have not been replicated.