Today at Examine.com, we’re bringing you a new page on Piceatannol, a molecule structurally very similar to the wine phenolic known as Resveratrol. Resveratrol was the first major 'stilbene' to be discovered, and research has since progressed to similar molecules in order to determine which offer the most benefits for the human body.

Piceatannol can be considered to be very similar to resveratrol, since their structures have only a few differences. Piceatannol boasts an anti-inflammatory mechanism (COX2 inhibition) that has been shown to be fairly potent in vitro. Piceatannol also inhibits a small protein known as Syk. Syk is involved in a variety of signaling pathways, so the potential of this inhibition is quite wide in scope.

Preliminary evidence suggests piceatannol could potentially be used as a replacement for Resveratrol, since it confers a few more anti-inflammatory properties (its inhibition of COX2 is more potent, for example). The ramifications of piceatannol’s Syk inhibition requires further study.

Though there is no human evidence on the topic yet, in vitro evidence suggests the two stilbenes are comparable in regard to resveratrol’s three major functions: antioxidant defense, blood flow, and potential anticancer properties. More evidence is needed to confirm the interchangeability of piceatannol and resveratrol. For now, Piceatannol remains a potential alternative.

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