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About the only study suggesting sweeteners could spike insulin was found in vitro rat pancreatic cells when coupled with glucose and done with direction transfusion (instead of ingested orally)
the data from extensive in vivo studies in human subjects show that low-energy sweeteners do not have any of the adverse effects predicted by in vitro, in situ or knockout studies in animals. 
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- Effects of oral ingestion of sucralose on gut hormone response and appetite in healthy normal-weight subjects. Eur J Clin Nutr. (2011) Ford HE, et al.
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- Sweet taste: effect on cephalic phase insulin release in men. Physiol Behav. (1995) Teff KL, Devine J, Engelman K.
- Effects of artificial sweeteners on insulin release and cationic fluxes in rat pancreatic islets. Cell Signal. (1998) Malaisse WJ, et al.
- Sweet-taste receptors, low-energy sweeteners, glucose absorption and insulin release. British Journal of Nutrition. (2010) Andrew G. Renwicka,Samuel V. Molinarya.
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