Study under review: A randomized controlled trial to test the effect of multispecies probiotics on cognitive reactivity to sad mood
For thousands of years, clinicians have observed a connection between the gut, brain, and overall health. Hippocrates is famously quoted as saying “all disease begins in the gut.” This should not come as a surprise to anyone who has ever experienced gastrointestinal (GI) symptoms like diarrhea, indigestion, or abdominal discomfort in response to changes in their emotional state. Studies in both healthy patients and in people with functional bowel disorders have confirmed connections between emotional state and GI function.
The gut and brain communicate through neural, endocrine and immune pathways. It has become increasingly clear that interactions with intestinal microbiota are also an important part of this communication. A number of animal and human studies have examined the relationship between gut bacteria and mood symptoms such as anxiety and depression, leading to the idea that probiotic supplementation may be a potential strategy for reducing or preventing depression.
According to the cognitive theory of depression, an individual's negative and distorted thinking is the basic psychological problem at the root of depressive syndrome. Cognitive reactivity refers to the activation of dysfunctional patterns of thinking triggered by subtle mood changes. This is a key feature in the development and occurrence of depression, and as such would be a relevant target for interventions. Dysfunctional patterns of thinking can include thoughts of hopelessness, thoughts of hurting oneself or others, ruminating on the causes and consequences of anguish, and a general loss of motivation for life. These responses are thought to come from underlying negative thought patterns that get brought to the surface during times of low mood. Cognitive reactivity appears to be a cause of, rather than simply an association with, depression, since higher cognitive reactivity scores precede and predict the onset of depression, even in people with no prior incidence of depression.
Considering the vast potential to treat and prevent mood disorders by improving gut health, the objective of this Dutch study was to determine the effects of a probiotic supplement on cognitive reactivity to sad mood, as well as symptoms of depression and anxiety in non-depressed, healthy adults.
Cognitive reactivity, which involves negative thought patterns triggered by mood change, has been shown to predict the onset of depression. Since the brain and gut communicate through several pathways and the gut microbiome has recently been found to influence this communication, it is possible that probiotic supplementation could affect cognitive reactivity. This is what this study set out to test.
Other Articles in Issue #08 (June 2015)
A hole in the bucket: gliadin and intestinal permeability
Understanding what happens at the intestinal barrier is key for understanding reactions to wheat.
Metabolic flexibility: The argument to use both carbs and fats
By Mike T. Nelson, PhD
Blast from the past: a paleo solution for type-2 diabetes
The evidence continues to build for ancestrally-influenced diets
Vitamin (K)ardiovascular health?
Results are in from the first long-term trial of vitamin K2 for cardiovascular health.
Big breakfast or big dinner? Yet another meal-timing study
Eating the exact same meals, but in a different order could help stabilize blood sugar.
Green tea extract may not be an equal opportunity fat loss supplement
Does this common fat loss supplement actually work? And how might it produce its effects?
Interview: Shawn Wells, MPH, RD - Part 2
Shawn Wells, MPH, RD, CISSN has a unique blend of knowledge in the field of performance nutrition and supplementation. Mr. Wells attended UNC-Chapel Hill, earning a Master’s degree in Nutrition and minor in Exercise Science. His education along with credentials of Registered Dietitian, Certified Sport Nutritionist (CISSN), and board member of the ISSN, distinguished him as an expert in sports nutrition.
Interview: Eric Helms, PhD(c)
A go-to source for natural contest prep, Eric gives us some sage advice on macros.