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Casting a wider net for marine oil’s cardiovascular benefits

We previously covered a major meta-analysis which found that marine-derived omega-3 supplementation didn't have clear cardiovascular benefits. However, three large trials have been released since then. Do they make a difference?

Study under review: Marine Omega-3 Supplementation and Cardiovascular Disease: An Updated Meta-Analysis of 13 Randomized Controlled Trials Involving 127 477 Participants.

Introduction

NERD #42, “A fishy relationship between omega-3 fatty acids and heart health” covered a 2018 meta-analysis[1] that examined the possible cardiovascular benefits of omega-3 fatty acids. That meta-analysis had several strengths: it was preregistered and aimed to collect the best evidence by only looking at larger, long term studies. And, it pretty much found no effect. However, three very large, long term trials looking at omega-3s’ ability to reduce cardiovascular disease risk have been published since then. The study under review aimed to update the 2018 meta-analysis with these three studies to determine if they change anything.

Who and what was studied?

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What were the findings?

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What does the study really tell us?

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The big picture

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Frequently asked questions

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Other Articles in Issue #61 (November 2019)