Study under review: Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality
Vitamin D is a fat-soluble nutrient and prohormone. It plays a critical role in bone formation, calcium metabolism, and also has an impact on immune function. As you can see in Figure 1, vitamin D levels are often low during pregnancy. Studies of vitamin D status in pregnant women have shown that low vitamin D levels can influence bone development in utero in the 19th week, and given the critical role of vitamin D in many features of growth development, it has been hypothesized that low levels of vitamin D might impact overall fetal health during pregnancy.
Previous randomized controlled trials have examined the role of vitamin D supplementation on maternal, neonatal, and infant outcomes. These studies yielded equivocal results, with inconsistent findings and methodologies across studies. As low vitamin D levels are reported at high levels in the maternal population, it is critical that a robust understanding of how vitamin D supplementation impacts fetal and neonatal development and growth is developed. The purpose of the present study was to assess the full body of literature and paint a clear picture of the effects of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality through a systematic review and meta-analysis of randomized controlled trials.
Vitamin D plays a critical role in growth in utero, yet deficiency occurs at high rates in pregnant women, worldwide. Randomized controlled trials examining the effect of vitamin D on offspring growth, morbidity, and mortality have yielded conflicting results. The study under review is a systematic review and meta-analysis of these randomized controlled trials aimed at examining the effect of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality.
Other Articles in Issue #45 (July 2018)
NERD mini: The International Olympic Committee’s take on what supplements actually work
The IOC released a consensus statement earlier this year chock full of information on dietary supplements. Here, we summarize what they said about which supplements have the best evidence base for athletes.
Is timing really everything?
Casein looks like a good candidate for a protein source that slowly releases amino acids into the body to help with overnight muscle building. But does it actually do any more if taken at night?
The ketogenic diet — there’s an app for that!
How much of an impact can intensive support combined with a ketogenic diet make on CVD risk markers and glycemic control in people with type 2 diabetes?
Aspartame: It’s sweet to eat, but is it a trick or a treat?
While you shouldn’t eat it by the bowl, it hardly affects glycemic control
You are what you eat, right?
This systematic review aimed to explore how some livestock-raising practices could influence human health.
Does the 16:8 fasting diet boost weight loss and health?
This pilot study examined how restricting feeding to eight hours a day every day affects the weight and metabolic health of people with obesity
NERD Mini: The latest skinny on polyunsaturated fats according to the Cochrane Collaboration
Want a very abbreviated summary of a series of recent meta-analyses examining PUFAs’ effects on cardiovascular health? We got you covered