Study under review: Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality
Vitamin D is a fat-soluble nutrient and prohormone. It plays a critical role in bone formation, calcium metabolism, and also has an impact on immune function. As you can see in Figure 1, vitamin D levels are often low during pregnancy. Studies of vitamin D status in pregnant women have shown that low vitamin D levels can influence bone development in utero in the 19th week, and given the critical role of vitamin D in many features of growth development, it has been hypothesized that low levels of vitamin D might impact overall fetal health during pregnancy.
Previous randomized controlled trials have examined the role of vitamin D supplementation on maternal, neonatal, and infant outcomes. These studies yielded equivocal results, with inconsistent findings and methodologies across studies. As low vitamin D levels are reported at high levels in the maternal population, it is critical that a robust understanding of how vitamin D supplementation impacts fetal and neonatal development and growth is developed. The purpose of the present study was to assess the full body of literature and paint a clear picture of the effects of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality through a systematic review and meta-analysis of randomized controlled trials.
Vitamin D plays a critical role in growth in utero, yet deficiency occurs at high rates in pregnant women, worldwide. Randomized controlled trials examining the effect of vitamin D on offspring growth, morbidity, and mortality have yielded conflicting results. The study under review is a systematic review and meta-analysis of these randomized controlled trials aimed at examining the effect of vitamin D supplementation during pregnancy on offspring growth, morbidity, and mortality.
Other Articles in Issue #45 (July 2018)
NERD mini: The International Olympic Committee’s take on what supplements actually work
The IOC released a consensus statement earlier this year chock full of information on dietary supplements. Here, we summarize what they said about which supplements have the best evidence base for athletes.
NERD Mini: The latest skinny on polyunsaturated fats according to the Cochrane Collaboration
Want a very abbreviated summary of a series of recent meta-analyses examining PUFAs’ effects on cardiovascular health? We got you covered
Is timing really everything?
Casein looks like a good candidate for a protein source that slowly releases amino acids into the body to help with overnight muscle building. But does it actually do any more if taken at night?
The ketogenic diet — there’s an app for that!
How much of an impact can intensive support combined with a ketogenic diet make on CVD risk markers and glycemic control in people with type 2 diabetes?
Aspartame: It’s sweet to eat, but is it a trick or a treat?
While you shouldn’t eat it by the bowl, it hardly affects glycemic control
You are what you eat, right?
This systematic review aimed to explore how some livestock-raising practices could influence human health.
Does the 16:8 fasting diet boost weight loss and health?
This pilot study examined how restricting feeding to eight hours a day every day affects the weight and metabolic health of people with obesity