The Nutrition Examination Research Digest (NERD) aims to provide rigorous, unbiased analysis of the latest and most important nutrition and supplementation studies. Click here to subscribe or login if already a subscriber .
Study under review: A possible link between early probiotic intervention and the risk of neuropsychiatric disorders later in childhood: a randomized trial
Introduction
Diagnoses of developmental disabilities in children are on the rise[1] in the United States, with increases in attention deficit hyperactivity disorder (ADHD) and autism spectrum disorders such as Asperger’s syndrome (AS) leading the trend. Knowing how to stem this tide would be useful. But how?
One tantalizing possibility may be probiotics. Research into the “gut-brain axis[2]” is a hot topic right now, one we’ve most recently explored in NERD #6 in the article “Can fiber change your emotions?” While the research is still young, mounting animal and human[3] evidence suggests that the gut microbiome can affect brain activity. Since developmental disorders such as ADHD and AS involve the brain, perhaps probiotic supplementation may affect these disorders as well. This idea is bolstered by the fact that many children on the autistic spectrum have concurrent gastrointestinal issues[4] and abnormal gut bacteria. Furthermore, one hypothesis[5] for how ADHD develops, at least in some cases, has to do with immunologic hypersensitivity to environmental triggers. And some of the authors of the study under review found[6] that probiotics are able to mitigate some aspects of this type of hypersensitivity in children.
The sum of these ideas suggest that probiotics in early life could influence the development of ADHD and AS later in life. This study intended to put this theory to the test.
Who and what was studied?
What were the findings?
What does the study really tell us?
The big picture
Frequently Asked Questions
What should I know?
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Going nuts over infant peanut exposure
Randomized trial of peanut consumption in infants at risk for peanut allergy.
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How the Food Industry Spins Science to Fit Its Agenda
By Andy Bellatti, MS, RD
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Non-celiac gluten sensitivity: much ado about something?
Some argue it doesn't exist... this latest trial sheds light into the controversy.
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Putting the “D” in Death
A reverse J-shaped association between serum 25- hydroxyvitamin D and cardiovascular disease mortality – the CopD-study
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Eggcellent Eggs: Is it safe for people with diabetes to eat a lot of eggs?
The effect of a high-egg diet on cardiovascular risk factors in people with type 2 diabetes: the Diabetes and Egg (DIABEGG) study—a 3-mo randomized controlled trial
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Do BCAAs and arginine prevent central fatigue during exercise?
Branched-chain amino acids and arginine improve performance in two consecutive days of simulated handball games in male and female athletes: a randomized trial
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HMB-elly be gone
β-Hydroxy-β-methylbutyrate (HMB) supplementation and resistance exercise significantly reduce abdominal adiposity in healthy elderly men
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Spicing up your workout
Curcumin supplementation likely attenuates delayed onset muscle soreness (DOMS)
- Interview: James Heathers, PhD
- Interview: Shawn Wells, MPH, RD