Study under review: A Systematic Review and Meta-Analysis of B Vitamin Supplementation on Depressive Symptoms, Anxiety, and Stress: Effects on Healthy and 'At-Risk' Individuals.
Mood disorders represent a category of mental illness that impact a person’s persistent emotional state. They affect nearly 21% of all adults in the U.S. at some point during their lives. The emotional states that mood disorders affect include depression, stress, and anxiety. Over the past several decades, there has been an increasing awareness about the relationship between diet and mental health, including mood disorders.
B vitamins have received extra attention as a dietary component of mood disorders because of their relationship to brain function. B vitamins play a role in brain chemistry, specifically related to mood, as they act as cofactors ultimately necessary for the synthesis of dopamine and serotonin, as shown in Figure 1. These neurotransmitters are both key components in regulating mood. Supplementation with B vitamins has a good safety profile and may have a lower risk of side effects than antidepressants.
There have been several investigations into the effect of B vitamin supplementation on many aspects of mood. For example, randomized controlled trials have shown that B vitamin supplementation improves depression, anxiety, and work-related stress. However, not all studies have shown benefit. As such, there is a need to examine the literature in a broader scope to understand the effect B vitamins might have on mood disorders. The present study was a systematic review and meta-analysis of randomized controlled trials examining the effect of B vitamins on mood.
B vitamins are critical components in the synthesis of neurotransmitters that regulate mood, such as dopamine and serotonin. Previous studies have yielded mixed results on the effects of vitamin B supplementation on mood disorders. The present study was a systematic review and meta-analysis of randomized controlled trials examining the effect of B vitamins on mood.
Other Articles in Issue #63 (January 2020)
Can lavender take the edge off anxiety?
Lavender seems to reduce non-clinical anxiety a bit according to this meta-analysis, but the evidence isn't all that strong.
Does the menstrual cycle affect caffeine’s performance-enhancing properties?
There's reason to suspect that caffeine's aerobic-boosting effects could vary depending on menstrual cycle phase. This is the first trial to directly explore the issue by comparing caffeine's effects during three different menstrual cycle phases.
Interview: Eric Russell Helms and Gary John Slater
In this info-packed interview, we pick the brain of two fitness researchers who recently wrote a comprehensive review examining the optimal energy surplus needed for hypertrophy.
Evaluating the safety and efficacy of very low calorie ketogenic diets
Very low calorie keto diets have a theoretical leg up on non-keto diets because they’re supposed to suppress appetite more. But whether they actually lead to more weight loss than non-keto very low calorie diets is far from clear.
Women and men appear to benefit equally from the ergogenic effects of coffee
There are some reasons to suspect that your sex can influence coffee's ergogenic effects. But whether this pans out in actual performance isn’t clear.
NERD Mini: What’s soy good for?
Soy’s been examined for a lot of health outcomes. But what outcomes does the evidence best support?
Does some cinnamon each day keep the cardiologist away?
A bit of this spice can keep blood pressure nice… but not as nice as exercise or pharmaceuticals can.