Quick Navigation

Does taking breaks from sitting improve glycemic control?

Background

Excessive sedentary time is associated with obesity, metabolic syndrome, and type 2 diabetes. Can taking more breaks from sitting improve the glycemic control and metabolic profile of sedentary adults with obesity?

The study

In this 4-week randomized controlled trial, 16 people aged 44–53 (BMI: ≥30) wore continuous glucose and activity monitors. After a baseline period (1 week), they were divided into two groups (3 weeks): a Frequent Activity Breaks from Sitting (FABS) group and a nonintervention control group. Every 30 minutes, a smartwatch app told the FABS group to exercise for 3 minutes at low-to-moderate intensity — by walking, stair-climbing, or doing body-weight squats, for instance.

Before and after the trial, five methods were used to assess glycemic control (the primary outcome): continuous glucose monitoring, oral glucose tolerance test (OGTT), homeostatic model of insulin resistance (HOMA-IR), hepatic insulin resistance index (HIRI), and Matsuda index. Two secondary outcomes were also assessed: clinical chemistry (via blood samples) and skeletal muscle lipidome (via vastus lateralis biopsies).

The results

FABS decreased glucose variation and fasting blood glucose levels, with greater daily activity yielding greater benefits. In contrast, glucose tolerance and average 24-hour glucose curves didn’t change.

FABS increased two long-chain triglycerides and nonsignificantly decreased LDL-C. Other blood markers and the skeletal muscle lipidome didn’t change.

All outcomes remained the same in the control group.

Note

The authors assessed only within group changes; they didn’t compare results between groups (the preferred method in randomized controlled trials).

Compared to baseline, the FABS group walked only 744 steps more (10.4 minutes) per day, with no changes in total sitting time or the number of transitions from sitting to standing.

There are 22 more summaries in the Diabetes & Blood Sugar category for August 2021 including ...

  • Lifestyle interventions for people with type 2 diabetes living in low-income and middle-income countries
  • The impact of vegan diets on type 2 diabetes
  • Could probiotic supplementation improve insulin sensitivity in obese children and adolescents?

Become an Examine Member to view the latest study summaries across 25 categories.