Issue #76 (February 2021)

• Safety spotlight: Sex, drugs, and weight loss supplements
  We give the lowdown on a recent FDA crackdown on sexual enhancement and weight loss supplements.
• Interview: Lauren Bruzzone, PhD, JD
  We chat with CrossFitter Lauren Bruzzone about how she's stayed fit throughout her life.
• Deep Dive: A heartbreaking story of EPA, DHA, and CVD
  A major study looking at how pharmaceutical-grade fish oil affects CVD risk came up empty-handed. We cover that trial here and discuss its possible ramifications.
• Deep Dive: Cutting carbs may help reverse diabetes, but dietary adherence remains a challenge
  Low-carb diets can reverse diabetes for some people, but they can be challenging to stick to, and longer-term efficacy remains uncertain.
• Curcumin reduces DOMS, with some caveats Open Access
  A recent meta-analysis suggests a modest effect of curcumin on delayed-onset muscle soreness, but the quality of evidence ain't great.
• Deep Dive: Keto, carbs, and calories
  A tightly-controlled experiment found that short-term keto led to more ad libitum food intake than a higher-carb diet, raising further doubts about the carbohydrate-insulin model of obesity.
• Evaluating the efficacy of vitamin D, omega-3, and strength training in older adults
  This large and meticulously designed trial explored whether supplementation or strength training improved the mental or physical health of people over 70. It came up empty-handed. The question is: why?
• Deep Dive: Zinc and immunity
  One big reason people take zinc is to boost immunity. This meta-analysis looked at the details of how supplementation impacted specific immune and inflammation markers.

Researchers

Antonis Damianou, MSc; Brad Dieter, PhD; Nick Milazzo, MS(c); Thomas Reichhart, MSc; Brandon Roberts PhD, MS, CSCS; Lucas Roldos, BSc, MSc(c); Jill Ryer-Powder, PhD; Detrick Snyder, MPH, RDN; Lucas Tafur, PhD; Nattha Wannissorn, PhD, RNH, FDN-P

Editors

Gregory Lopez, MA, PharmD

Reviewers

Stephan Guyenet, PhD & Adel Moussa, PhD

Copy Editor

Dmitri Barvinok

Infographics

Antonius Khengdro & Calla Lee