Issue #75 (January 2021)

• Safety Spotlight: Women and creatine
  The effects of creatine are quite well studied, but its sex-specific safety profile hasn't been. Besides some non-serious side effects, creatine seems safe for women, but more work needs to understand creatine's effects during pregnancy.
• The effects of increased protein intake on overall energy intake in older adults
  Boosting protein intake may help stave off the loss of muscle strength and function that can come with age. But does increasing protein affect energy intake in older adults as well? We cover a recent meta-analysis that explored this question.
• Sugar Wars, Episode 6: The Return of the Fructose Open Access
  How does fructose affect cardiometabolic risk markers calorie-for-calorie compared to glucose or sucrose? This recent meta-analysis aimed to find out.
• Deep Dive: Supplementing for senior strength and size in the context of sarcopenia
  This systematic review and meta-analysis explored what supplements can stave off the loss of muscle function that comes with aging. However, the way it categorized the studies it used, along with the overall low quality of those studies, makes its conclusions seem a bit... weak.
• Interview: Cyriac Abby Philips, MBBS, MD, DM (Hepatology) Open Access
  In this interview, we pick Dr. Philips' brain about the basics of Ayurveda, its safety, and the story behind a recently retracted paper he was involved with detailing a case of acute liver failure and death in a patient who was taking supplements.
• Deep Dive: Comparing the efficacy of diet, exercise, and lifestyle modifications for controlling childhood obesity
  This meta-analysis looked at what lifestyle interventions work best for children with overweight and obesity, and how much of a role parental involvement played.
• Deep Dive: Do Low-Carb Diets Stoke the Metabolic Fire?
  This meta-analysis concluded that longer-term low-carb dieters feel the metabolic burn, but some methodological concerns may douse this flame a bit.
• Deep Dive: Evaluating the relationship between training status and optimal protein intake
  According to this recent meta-analysis, whether or not more protein is better for lean body mass may come down to resistance training status.

Researchers

Antonis Damianou, MSc; Brad Dieter, PhD; Nick Milazzo, MS(c); Thomas Reichhart, MSc; Brandon Roberts PhD, MS, CSCS; Lucas Roldos, BSc, MSc(c); Jill Ryer-Powder, PhD; Detrick Snyder, MPH, RDN; Lucas Tafur, PhD; Nattha Wannissorn, PhD, RNH, FDN-P

Editors

Gregory Lopez, MA, PharmD

Reviewers

Stephan Guyenet, PhD & Adel Moussa, PhD

Copy Editor

Dmitri Barvinok

Infographics

Antonius Khengdro & Calla Lee