Study under review: Lactobacillus reuteri reduces bone loss in older women with low bone mineral density: a randomized, placebo-controlled, double-blind, clinical trial
Osteoporosis is a chronic disease characterized by a lowered bone mineral density (BMD) that can lead to debilitating bone fractures. It is estimated to affect 9.9 million adults in the U.S., while another 43.1 million have osteopenia, the condition between normal bone density and osteoporosis. Postmenopausal women have the greatest risk of developing osteopenia or osteoporosis.
The first line of recommended treatments by the National Osteoporosis Foundation is modifying the diet to include adequate amounts of calcium and vitamin D, and engaging in regular weight-bearing exercise to maintain bone strength. However, research over the past few years has suggested that the gut microbiome and probiotic therapy can play a role in bone health. Some researchers have gone so far as to coin a term for this relationship: “gut microbiota-bone axis.”
Of particular interest is a species of lactic acid producing bacteria called Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475). Several studies using mice have shown L. reuteri 6475 can increase BMD and reduce bone loss. However, to date, there have been no human interventions examining the link between this organism and bone health. The randomized, controlled human trial reviewed here is the first such human study.
Osteoporosis and osteopenia are diseases of bone loss often managed through diet and exercise. Emerging evidence indicates the gut microbiome plays a role in bone health, and several animal studies have suggested that Lactobacillus reuteri ATCC PTA 6475 (L. reuteri 6475) can increase bone mineral density and reduce bone loss. The study under review is the first human intervention to evaluate how L. reuteri 6475 affects bone health.
Other Articles in Issue #47 (September 2018)
Betaine: Can it improve body composition and performance in women?
This is the first study to look at betaine's effects on body composition and performance in women who have just started lifting.
Smackdown: Whole grains versus fruits and vegetables effects on inflammation and the gut microbiome
Overweight and obesity can be accompanied by subclinical inflammation, which may be tied in part to the gut microbiome. This study aimed to find out how increasing fruit and veggie or whole grain intake affects these.
Which oils or fats have the best effect on cholesterol?
Different oils and fats can have very different effects on blood lipids. This network meta-analysis explored exactly how different the effects are.
Mini: What’s healthy about chocolate?
We summarize which health claims about chocolate have some evidence to back them up according to a recent umbrella review on the matter.
Cheese reloaded: enter the matrix
Context matters when it comes to macronutrients’ impact on lipid levels.
Fighting fat with fat: omega-3s vs. NAFLD
Diet and exercise are some of the main ways to fight non-alcoholic fatty liver disease. This meta-analysis examined whether n-3 supplementation could be added to the list.
Mini: The sports supplements with the highest amount of evidence according to the ISSN
We summarize which supplements have the best evidence base for muscle building and performance enhancement according to the ISSN’s recently updated sports nutrition review.