Study under review: Vitamin C–enriched gelatin supplementation before intermittent activity augments collagen synthesis
The collagen-rich extracellular matrix may be among the most underappreciated parts of the musculoskeletal system. It is required for proper functioning of the tendons, ligaments, cartilage, skin, and bone. For this matrix to function, an adequate amount of collagen and collagen crosslinking, along with water and minerals inside the tissue, is needed. Nutritional inadequacy and disease states can weaken connective tissue and leave it prone to breaking down from normal mechanical demands such as walking and even moderate exercise. In contrast, adequate nutrition and exercise are able to improve the functioning of the extracellular matrix, and collagen synthesis can be increased by an acute bout of exercise. The purpose for increasing collagen synthesis is to create denser and stiffer tissue, which can withstand higher loads.
In vitro studies from engineered models of tendons and ligaments have shown that the presence of vitamin C and the amino acid proline can increase collagen production (shown in Figure 1), while increasing the amino acid glycine can improve tendon recovery from inflammation and make tendons more resistant to rupture. Up until this point, the combination of nutritional intervention and acute exercise bouts have not been studied with regard to their synergistic effects on collagen synthesis. With this in mind, researchers set up a study in humans to determine if consuming gelatin (a food derived from collagen and rich in proline and glycine) and vitamin C combined with exercise could increase collagen synthesis in healthy adult males.
Reference: Shoulders et al. Annu Rev Biochem. 2009.
A collagen-rich extracellular matrix is a critical part of a healthy musculoskeletal system. In addition to exercise, nutritional components such as vitamin C and the amino acids proline and glycine also play a role in collagen synthesis. This study was setup to determine whether gelatin supplementation (rich in proline and glycine) with vitamin C could increase collagen synthesis when taken before an acute bout of exercise.
Other Articles in Issue #26 (December 2016)
What happens to diets when you control food quality?
Dieters often control their intake of either carbs or fat. But when dieting, the overall quality of food you eat can also change. Do low-fat and low-carb diet effects differ, even if you control for food quality?
Can diet soda ruin your diet?
Evidence is still quite mixed when it comes to diet soda effects on weight loss (or gain). Observational evidence often contradicts with trial evidence. This study adds to the body of evidence, specifically on those with type 2 diabetes.
Interview: Dr. Taylor Wallace, PhD
Dr. Wallace has done research in a variety of areas, including anthocyanins in plants. Here, we ask him about topics ranging from food additives to supplement side effects.
Cut out FODMAPs, cut out IBS symptoms?
If you have IBS, you know that physicians often lack well-supported dietary recommendations, so new research can be extremely valuable. This study is the first meta-analysis on the low-FODMAP strategy for curbing IBS symptoms
Can probiotics help with Alzheimer’s?
With an aging population, more and more people know someone with Alzheimer’s. As a disease of the brain, symptoms could be helped by supporting an organ that plays directly into brain health: the gut.
Curcumin for a clear nose
There are two types of people in the world: those who get seasonal allergies, and those who don’t. If you sneeze and wheeze, this trial on curcumin for allergic rhinitis provides must-read information.
Interview: Grant Tinsley, PhD
Remember that neat intermittent fasting study in the previous issue of NERD? We were lucky enough to interview one of the study authors, Grant Tinsley.