Examine publishes rigorous, unbiased analysis of the latest and most important nutrition and supplementation studies each month, available to all Examine Members. Click here to learn more or log in.

In this article

Dead, yet active probiotics?

We know that the gut microbiome can play a major role in a variety of conditions, but the specifics are still being teased out. This study tested the effect of one particular strain called Pediococcus pentosaceus LP28, in a heatkilled formulation.

Study under review: Antiobesity effect of Pediococcuspentosaceus LP28 on overweight subjects:a randomized, double-blind, placebocontrolled clinical trial

Introduction

There is no shortage of research investigating the interaction between the gut microbiome and obesity. Stemming from this research are trials that look at how supplementation of certain bacterial strains (probiotics) may impact weight status. There are at least three organisms[1] that have shown promise for reducing fat mass and inhibiting weight gain in humans so far: Lactobacillus gasseri SBT 2055, Lactobacillus rhamnosus ATCC 53103, and the combination of L. rhamnosus ATCC 53102 and Bifidobacterium lactis Bb12.

What the above bacteria have in common is that they are all classified as lactic acid bacteria (LAB). As the name implies, these bacteria produce lactic acid as the major end product of carbohydrate fermentation, which is pictured in Figure 1. It is thanks to this group of organisms that we are able to enjoy the sour taste of yogurt, kefir, cheese, sauerkraut, kimchi, and sourdough bread, to name a few commonly eaten fermented foods. These bacteria are also some of the first to populate the infant gut, as they are present[2] on the breast skin and in the breast milk of breastfeeding mothers.

Figure 1: How lactic acid bacteria produce lactic acid

The representative genera of LAB are Lactobacillus, Leuconostoc, Pediococcus, Streptococcus, and Bifidobacterium. Within each of these genera are numerous species that have their own particular fermentation reactions and niches. This diversity makes them very adaptable to a range of conditions and is largely responsible for their success in food fermentation. One particular species of LAB with the potential for obesity management is Pediococcus pentosaceus LP28 (LP28). This strain was shown to reduce[3] body weight gain, visceral fat, and liver fat in diet-induced obese mice. Now, these same researchers sought to evaluate whether LP28 is effective for reducing bodyweight and fat mass among overweight individuals.

Some probiotics have shown promise in reducing fat mass in humans. The current study sought to investigate the effects of another probiotic, Pediococcus pentosaceus LP28, in overweight individuals.

Who and what was studied?

Become an Examine Member to read the full article.

Becoming an Examine Member will keep you on the cutting edge of health research with access to in-depth analyses such as this article.

You also unlock a big picture view of 400+ supplements and 600+ health topics, as well as actionable study summaries delivered to you every month across 25 health categories.

Stop wasting time and energy — we make it easy for you to stay on top of nutrition research.

Try free for two weeks

Already a member? Please login to read this article.

What were the findings?

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

What does the study really tell us?

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

The big picture

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

Frequently Asked Questions

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

What should I know?

Become an Examine Member to unlock this article.

Free 2-week trial »

Already a member? Please login to read this article.

Other Articles in Issue #20 (June 2016)

  • D-fending against dermatitis
    Atopic dermatitis, otherwise known as eczema, isn’t an easily treatable condition. This systematic review looked at whether vitamin D supplementation may help reduce the symptoms of atopic dermatitis
  • Interview: Rick Miller, MSc, RD
    Most cows provide milk that contains at least some of a protein called A1 betacasein. Rick explains the difference between A1 and A2 beta-casein, and what benefits may be associated with A2 milk.
  • Mamas, don’t let your babies grow up to be gluten intolerant
    We’ve previously covered peanut introduction in infants, and next up is gluten introduction. These researchers analyzed the changing literature looking at celiac disease risk when gluten is introduced at different times.
  • Do probiotics alter gut microbiome composition?
    Probiotic ads tout the number of live bacteria they contain, typically numbering in the billions. But our guts already contain trillions of bacteria. Do probiotics actually change the makeup of our microbiomes?
  • Fattening up breakfast for weight loss
    Calories are the most important weight loss factor, but not the only one. It turns out that the type of fats you eat may impact your appetite, and this trial tested two fats (CLA and MCT) for that purpose.
  • Carnosine for blood sugar control
    If you join together the amino acids l-histadine and beta-alanine, you get the dipeptide called carnosine. Carnosine may have a variety of benefits, and this trial tested carnosine’s specific effect on insulin dynamics.
  • Coenzyme Q10 and chronic fatigue syndrome
    Chronic fatigue syndrome is a life-changing condition without many effective treatments. Could daily supplementation with coenzyme Q10 be a simple way to improve symptoms?
  • Can arachidonic acid work as a bodybuilding supplement?
    There isn’t nearly as much research on potential benefits of omega-6 fatty acids as there is on omega-3s. This study looked at the effect of the omega-6 known as arachidonic acid on resistance exercise