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Study under review: Resveratrol induces brown-like adipocyte formation in white fat through activation of AMP-activated protein kinase (AMPK) α1
Resveratrol, an antioxidant commonly found in red wine, was supposed to be the breakout supplement of our time. Many media outlets have praised its anti-cancer, anti-aging, and anti-heart disease properties. The anti-aging claims drew the most attention, as resveratrol seemed to act as a "calorie restriction mimetic" and was theorized to slow aging and reduce the risk of age-related diseases. While there have been many promising animal studies, these miraculous benefits have not panned out in human trials.
In Study Deep Dives #2, we reviewed the ergogenic effects of resveratrol in the context of high-intensity interval training and found that it was unlikely to increase performance and may even impair training adaptations. Even though most positive health outcomes seen in the animal models don’t usually manifest in humans, there remains a chance that resveratrol supplementation could moderately improve metabolic markers for insulin sensitivity and cardiovascular health.
The article reviewed here continues to expand our knowledge of how resveratrol operates, inching us closer toward a potentially practical use for the supplement. The study under review examined the effect of resveratrol supplementation on what is known as beige or ‘brown-like’ adipose tissue. The human body contains three distinct types of adipose tissue: white, brown, and beige fat. The basic characteristics of these are described in the sidebar.
Other Articles in Issue #09 (July 2015)
Got Milk (fat globule membrane)?
Butter and milk don’t have the same impact on heart disease, and their fat structures may help explain why.
The sweet release of biological stress markers
Sugar really hits the spot when you’re stressed out — but what is the physiological reason?
Citrulline wants to pump you up!
Nitric oxide is all the rage, but confusion abounds on what works.
I’m not too tired to stuff my face
Sleep deprivation and overeating often go hand in hand. This study quantifies the phenomenon.
Fructose: the sweet truth
This rat study seeks to differentiate the obesogenic effects of fructose from glucose.
Something fishy: How a component of fish oil may counteract the effects of some chemotherapy
Fish oil isn’t necessarily benign ... it turns out that certain fatty acids might partially negate chemotherapy.
Beet out your competition with dietary nitrate!
Beets have shown promise for solo exercise, but what about for longer activity typical of team sports?
- Interview: Bianca Arendt, PhD
- Interview: Grzegorz Palczewski PhD(c)