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Study under review: Alpha-lipoic acid supplement in obesity treatment: A systematic review and metaanalysis of clinical trials
Alpha-lipoic acid (ALA) is a naturally occurring antioxidant synthesized in small amounts by plants and animals, including humans. It plays an important role as a cofactor for several mitochondrial functions necessary for energy production and the metabolism of amino acids. Additionally, ALA can directly neutralize free radicals and regenerate other important antioxidants, such as vitamins C and E and glutathione, as shown in Figure 1.
One hypothesis to explain the exacerbation of obesity and associated complications is that a low-grade inflammatory state promotes oxidative stress that blunts the use of fat as an energy source and facilitates fat storage. It has been proposed that oxidative stress increases as body fat accumulates, which contributes to the development of cardiometabolic diseases. Therefore, antioxidants like ALA have been suggested to have potential therapeutic value in treating obesity.
Aside from antioxidant functions, ALA could hypothetically benefit obesity through its effects on AMPK in fat, muscle, and the liver that result in improved glucose uptake and fat oxidation. ALA has also been demonstrated to inhibit AMPK in the hypothalamus, leading to the suppression of appetite and food intake in rodents. The reduction in food intake appears to range from 18-30% relative to unsupplemented control animals. Additionally, ALA may be able to reduce glucose absorption in the intestines secondary to inhibiting its transporter. Other research in mice has reported that ALA supplementation increases energy expenditure and reduce fat synthesis in the liver.
Several clinical trials looking at the effect of ALA supplementation on weight loss in humans have been conducted, but their results have been conflicting. The study under review is a meta-analysis that sought to address this issue by quantifying the efficacy of supplemental ALA on bodyweight and BMI in adults, using data from randomized controlled trials.
Alpha lipoic acid (ALA) is a naturally occurring antioxidant believed to have potential for the treatment of obesity. ALA supposedly works by reducing the oxidative stress associated with obesity, suppressing food intake, reducing nutrient absorption, increasing energy expenditure, and reducing fat synthesis. The study under review is a meta-analysis of randomized controlled trials that sought to quantify the efficacy of ALA on bodyweight and BMI in adults.
Other Articles in Issue #35 (September 2017)
Interview: Brad Dieter, PhD
In this interview, we pick Brad’s brain on a number of topics, including diabetic kidney disease, science writing, and the possibility of nominative determinism involving his last name!
Interview: Margaret Leitch, PhD
In this interview with experimental psychologist Margaret Leitch, we discuss the psychology of weight loss, the utility of statistics for researchers, and maternal nutrition.
Fish Oil Supplementation for Insulin Resistance: Nothing but a Fish Burp?
Fish oil has been studied a lot for numerous health claims, including improving insulin resistance. But quantity does not necessarily equal quality.
Can probiotics help with inflammatory bowel disease?
A older meta-analysis surprisingly found that probiotics do not have a clear effect on IBD. Since then, new research has come to light.
Can the Mediterranean Diet curtail inflammation in Type 2 diabetes?
Evidence suggests that the Mediterranean diet can be beneficial for people with diabetes. Those benefits may also extend to inflammation.
A bit of caffeine may help the antidepressants go down
Antidepressants typically take a while to start working. Can caffeine help them kick in faster?
Stepping up weight loss: Can walking help dieters shed fat?
Walking doesn't do much for fat loss on its own. But there's reason to suspect it could boost the benefits of a caloric deficit.