Examine publishes rigorous, unbiased analysis of the latest and most important nutrition and supplementation studies each month, available to all Examine Members. Click here to learn more or log in.

In this article

Better living through cherry juice

Cherries and berries (the former is not a type of the latter, by the way) have increasingly shown cognitive benefits. This trial specifically explores cherries for Alzheimer’s disease.

Study under review: Consumption of anthocyanin-rich cherry juice for 12 weeks improves memory and cognition in older adults with mildto-moderate dementia


Plant-based[1] foods have been contributing positively to human health since time immemorial. More recently, these health effects have been widely attributed to phytochemicals, a group of non-nutritive bioactive compounds generally found in fruits, vegetables, whole grains, nuts, and legumes.

In the fields of neuroprotection and cognitive functioning, plants are once again at the forefront of cutting-edge science: flavonoids, a category of phytochemicals, have been associated with improved cognitive function and reduced neurodegenerative decline in old age. In fact, two studies reported that daily consumption of either wild blueberry juice or concord grape[2] juice for 12 weeks led to improvements in verbal learning and memory in older adults with mild cognitive impairment. A more recent study extended these findings to older adults with no sign of cognitive impairment, reporting that daily consumption of flavanone-rich orange juice[3] for eight weeks seemed to improve overall cognitive performance.

As promising as this sounds, the research is still lacking in individuals that have dementia, a blanket term for various neurodegenerative diseases that are believed to compromise the areas of the brain associated with “higher brain functions,” such as language, memory, learning, and self-awareness. Dementia progresses to the point that the individual eventually finds it difficult to perform day-to-day activities and live independently.

Alzheimer’s disease[4] (AD), the most common form of dementia, is the sixth leading cause of death in America. At the time of this writing, approximately 5.3 million Americans live with AD. By 2050, this number is projected to increase to about 15.3 million (almost a 300% increase) as members of the baby boomer generation age. In light of this rapid rise of AD and the lack of effective treatments, it’s important to conduct further studies examining the effect of fruit flavonoids on cognitive function in individuals with AD.

Therefore, the authors of this study sought to analyze the effects of sweet cherry juice, another flavonoid-abundant fruit (primarily through flavonoid subgroup anthocyanins) on the cognitive performance of individuals with mild-to-moderate AD.

Many of the health-conferring effects of plant-based foods may be attributed to their phytochemical content. Fruits rich in flavonoids, a class of phytochemicals, have recently shown promise in improving cognitive function and attenuating neurodegenerative decline. Unfortunately, research on this topic is lacking in people with Alzheimer’s disease, the sixth leading cause of death in America. The purpose of this study was to analyze the effect of daily consumption of flavonoid-rich sweet cherry juice for 12 weeks on the cognitive performance of elderly adults with mild-to-moderate Alzheimer’s disease.

Who and what was studied?

Become an Examine Member to read the full article.

Becoming an Examine Member will keep you on the cutting edge of health research with access to in-depth analyses such as this article.

You also unlock a big picture view of 400+ supplements and 600+ health topics, as well as actionable study summaries delivered to you every month across 25 health categories.

Stop wasting time and energy — we make it easy for you to stay on top of nutrition research.

Try free for two weeks

Already a member? Please login to read this article.

What were the findings?

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

What does the study really tell us?

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

The big picture

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

Frequently Asked Questions

Become an Examine Member to unlock this article.

Already a member? Please login to read this article.

What should I know?

Become an Examine Member to unlock this article.

Free 2-week trial »

Already a member? Please login to read this article.

Other Articles in Issue #15 (January 2016)

  • DASH plus fat equals ...
    The DASH diet is one of the most studied diets of all time, and was specifically formulated to curb chronic disease. But will DASH still do it’s thing if you add extra fat each day?
  • Wine and dine with diabetes
    For some, wine is a daily or weekly indulgence. As those with type 2 diabetes must pay extra attention to the blood sugar and lipid impact of what they consume, this trial puts red and white wine to the test.
  • Interview: Victoria Prince, MD, PhD
    Victoria Prince is passionate about ancestral health and evolutionary medicine, and has a particular interest in dietary fats and the role they play in health and disease, especially liver disease. She writes at principleintopractice.com.
  • The chocolate fountain of youth
    Cocoa contains high levels of beneficial phytochemicals called “flavanols”, which may provide a variety of health benefits. This randomized trial tested cocoa for the specific purpose of wrinkle reduction and other skin-related improvements.
  • Beyond ‘eat less, move more’: treating obesity in 2016
    By Spencer Nadolsky, DO
  • A fishy depression treatment
    With many trials already conducted on the topic of fish oil and depression, the question of overall impact still remained. This is the latest update to the Cochrane systematic review on the topic.
  • A calorie is a calorie ... or is it?
    Obesity research typically focus on what you eat, but less frequently touches on when you should eat it. Since animal models have shown strong results for meal timing, this study looked at potential weight-related benefits of eating earlier in humans.
  • A bit of D for CVD
    Vitamin D is touted for pretty much every health condition out there. While observational evidence has strongly linked optimal vitamin D levels to cardiovascular disease, the trial evidence has been more mixed. This trial attempts to strengthen that literature base.
  • Your probiotic may be lying to you
    Take a gander at a probiotic bottle label and you may be astounded at the number of live bacteria, as well as the variety these supplements contain. But the labels may not be entirely accurate