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ERD Mini: Do longer term, large doses of vitamin D have any adverse effects?

As more people take vitamin D, doses can creep up, whether from daily supplementation or large, periodic bolus doses. This meta-analysis examined whether larger doses of vitamin D over longer periods of time have any adverse effects.

Study under review: Adverse events from large dose vitamin D supplementation taken for one year or longer.

What was studied?

The meta-analysis looked for trials that lasted at least a year, and used average daily doses of vitamin D2 or D3 of 2,800 IU per day or more. They chose this rather specific number so that their analysis would capture common bolus doses that aren’t given daily, such as 100,000 IU every month. However, any dosing scheme (daily, monthly, or yearly) was included, as long as the average daily dose was at least 2,800 IU.

The researchers found 15 studies involving 3,150 people that met their criteria. The average dose was 9,990 IU per day, ranging from 2,857 to 100,000 IU daily. The studies lasted from one to five years.

What were the major findings?

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What’s the take-home?

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