Do artificial sweeteners spike insulin?

There is no evidence that artificial sweeteners cause an insulin spike in humans.


Protein can cause a spike in Insulin, but not aspartame[6]. Furthermore, consuming aspartame with or without carbohydrates resulted in aspartame not contributing to an insulin spike[7].

Diabetics were found to have no spike in insulin after ingesting nonnutritive sweeteners.[8] Swishing a solution in the mouth had no effect.[9]

About the only study suggesting sweeteners could spike insulin was found in vitro rat pancreatic cells when coupled with glucose and done with direction transfusion (instead of ingested orally).[10]