VO2 Max

VO2 Max refers to the maximal oxygen consumption during exercise, and is thought to reflect the abilities of the cardiorespiratory system (heart and lungs) to handle high intensity cardiovascular exercise (anaerobic exercise).

   

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect VO2 Max
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
SupplementChange
Magnitude of Effect Size
Scientific ConsensusComments
BCreatine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
BBeta-Alanine
BFish Oil
BSodium Bicarbonate
BColostrum
CCoenzyme Q10
CVitamin C
CEchinacea
CCordyceps
CRhodiola Rosea
CCaffeine
CGreen Tea Catechins
CL-Carnitine
CAshwagandha
CCurcumin
CCapsaicin
CTrimethylglycine
DEleutherococcus senticosus
DHMB
DMarijuana

References

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  2. Steadward RD, Singh M. The effects of smoking marihuana on physical performance. Med Sci Sports. (1975)
  3. Renaud AM, Cormier Y. Acute effects of marihuana smoking on maximal exercise performance. Med Sci Sports Exerc. (1986)
  4. Ramesh D1, Haney M, Cooper ZD. Marijuana's dose-dependent effects in daily marijuana smokers. Exp Clin Psychopharmacol. (2013)
  5. Cooper ZD1, Haney M. Opioid antagonism enhances marijuana's effects in heavy marijuana smokers. Psychopharmacology (Berl). (2010)
  6. Zajicek JP1, et al. Multiple sclerosis and extract of cannabis: results of the MUSEC trial. J Neurol Neurosurg Psychiatry. (2012)
  7. Zajicek J1, et al. Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis (CAMS study): multicentre randomised placebo-controlled trial. Lancet. (2003)
  8. Zajicek JP1, et al. Cannabinoids in multiple sclerosis (CAMS) study: safety and efficacy data for 12 months follow up. J Neurol Neurosurg Psychiatry. (2005)
  9. Freeman RM1, et al. The effect of cannabis on urge incontinence in patients with multiple sclerosis: a multicentre, randomised placebo-controlled trial (CAMS-LUTS). Int Urogynecol J Pelvic Floor Dysfunct. (2006)
  10. Aragona M1, et al. Psychopathological and cognitive effects of therapeutic cannabinoids in multiple sclerosis: a double-blind, placebo controlled, crossover study. Clin Neuropharmacol. (2009)
  11. Gorelick DA1, et al. Tolerance to effects of high-dose oral δ9-tetrahydrocannabinol and plasma cannabinoid concentrations in male daily cannabis smokers. J Anal Toxicol. (2013)
  12. Benowitz NL, Jones RT. Cardiovascular effects of prolonged delta-9-tetrahydrocannabinol ingestion. Clin Pharmacol Ther. (1975)
  13. Mathew RJ1, et al. Middle cerebral artery velocity during upright posture after marijuana smoking. Acta Psychiatr Scand. (1992)
  14. Mathew RJ1, et al. Regional cerebral blood flow after marijuana smoking. J Cereb Blood Flow Metab. (1992)
  15. Mathew RJ1, Wilson WH, Davis R. Postural syncope after marijuana: a transcranial Doppler study of the hemodynamics. Pharmacol Biochem Behav. (2003)
  16. Hollister LE, et al. 1 -tetrahydrocannabinol, synhexyl and marijuana extract administered orally in man: catecholamine excretion, plasma cortisol levels and platelet serotonin content. Psychopharmacologia. (1970)
  17. Merritt JC, et al. Effect of marihuana on intraocular and blood pressure in glaucoma. Ophthalmology. (1980)
  18. Flom MC, Adams AJ, Jones RT. Marijuana smoking and reduced pressure in human eyes: drug action or epiphenomenon. Invest Ophthalmol. (1975)
  19. Tomida I1, et al. Effect of sublingual application of cannabinoids on intraocular pressure: a pilot study. J Glaucoma. (2006)
  20. Lee MC1, et al. Amygdala activity contributes to the dissociative effect of cannabis on pain perception. Pain. (2013)
  21. Wallace M1, et al. Dose-dependent effects of smoked cannabis on capsaicin-induced pain and hyperalgesia in healthy volunteers. Anesthesiology. (2007)
  22. Kraft B1, et al. Lack of analgesia by oral standardized cannabis extract on acute inflammatory pain and hyperalgesia in volunteers. Anesthesiology. (2008)
  23. Martín-Sánchez E1, et al. Systematic review and meta-analysis of cannabis treatment for chronic pain. Pain Med. (2009)
  24. Ramaekers JG1, et al. High-potency marijuana impairs executive function and inhibitory motor control. Neuropsychopharmacology. (2006)
  25. Pletcher MJ1, et al. Association between marijuana exposure and pulmonary function over 20 years. JAMA. (2012)

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