Uric Acid

Uric acid is a molecule (a byproduct of purine metabolism) that, in excessive levels, can contribute to gout and kidney stones. Despite this, uric acid is a potent antioxidant compound.

   

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Uric Acid
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
SupplementChange
Magnitude of Effect Size
Scientific ConsensusComments
CCreatine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
CGanoderma lucidum
CGynostemma pentaphyllum
CL-Carnitine
CGlutamine
CQuercetin
CNigella sativa
CRooibos
CPsyllium
CCocoa Extract
DHibiscus sabdariffa
DTetradecyl Thioacetic Acid
DGarlic

References

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  2. Ried K, Frank OR, Stocks NP. Aged garlic extract reduces blood pressure in hypertensives: a dose-response trial. Eur J Clin Nutr. (2013)
  3. Dhawan V, Jain S. Garlic supplementation prevents oxidative DNA damage in essential hypertension. Mol Cell Biochem. (2005)
  4. Ma JL, et al. Fifteen-year effects of Helicobacter pylori, garlic, and vitamin treatments on gastric cancer incidence and mortality. J Natl Cancer Inst. (2012)
  5. You WC, et al. Randomized double-blind factorial trial of three treatments to reduce the prevalence of precancerous gastric lesions. J Natl Cancer Inst. (2006)
  6. Sobenin IA, et al. Lipid-lowering effects of time-released garlic powder tablets in double-blinded placebo-controlled randomized study. J Atheroscler Thromb. (2008)
  7. Scharbert G, et al. Garlic at dietary doses does not impair platelet function. Anesth Analg. (2007)
  8. Kojuri J, Vosoughi AR, Akrami M. Effects of anethum graveolens and garlic on lipid profile in hyperlipidemic patients. Lipids Health Dis. (2007)
  9. Adler AJ, Holub BJ. Effect of garlic and fish-oil supplementation on serum lipid and lipoprotein concentrations in hypercholesterolemic men. Am J Clin Nutr. (1997)
  10. Steiner M, et al. A double-blind crossover study in moderately hypercholesterolemic men that compared the effect of aged garlic extract and placebo administration on blood lipids. Am J Clin Nutr. (1996)
  11. Mader FH. Treatment of hyperlipidaemia with garlic-powder tablets. Evidence from the German Association of General Practitioners' multicentric placebo-controlled double-blind study. Arzneimittelforschung. (1990)
  12. Silagy C, Neil A. Garlic as a lipid lowering agent--a meta-analysis. J R Coll Physicians Lond. (1994)
  13. Mozaffari-Khosravi H, et al. The effect of garlic tablet on pro-inflammatory cytokines in postmenopausal osteoporotic women: a randomized controlled clinical trial. J Diet Suppl. (2012)
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  15. Stevinson C, Pittler MH, Ernst E. Garlic for treating hypercholesterolemia. A meta-analysis of randomized clinical trials. Ann Intern Med. (2000)
  16. Budoff MJ, et al. Inhibiting progression of coronary calcification using Aged Garlic Extract in patients receiving statin therapy: a preliminary study. Prev Med. (2004)
  17. Steiner M, Lin RS. Changes in platelet function and susceptibility of lipoproteins to oxidation associated with administration of aged garlic extract. J Cardiovasc Pharmacol. (1998)
  18. Rahman K, Billington D. Dietary supplementation with aged garlic extract inhibits ADP-induced platelet aggregation in humans. J Nutr. (2000)
  19. Steiner M, Li W. Aged garlic extract, a modulator of cardiovascular risk factors: a dose-finding study on the effects of AGE on platelet functions. J Nutr. (2001)
  20. Morris DM, Beloni RK, Wheeler HE. Effects of garlic consumption on physiological variables and performance during exercise in hypoxia. Appl Physiol Nutr Metab. (2013)
  21. Verma SK, et al. Effect of garlic (Allium sativum) oil on exercise tolerance in patients with coronary artery disease. Indian J Physiol Pharmacol. (2005)
  22. Bhattacharyya M, et al. Systemic production of IFN-alpha by garlic (Allium sativum) in humans. J Interferon Cytokine Res. (2007)
  23. Ried K, Toben C, Fakler P. Effect of garlic on serum lipids: an updated meta-analysis. Nutr Rev. (2013)
  24. Jepson RG, Kleijnen J, Leng GC. Garlic for peripheral arterial occlusive disease. Cochrane Database Syst Rev. (2013)
  25. Kiesewetter H, et al. Effects of garlic coated tablets in peripheral arterial occlusive disease. Clin Investig. (1993)
  26. Koscielny J, et al. The antiatherosclerotic effect of Allium sativum. Atherosclerosis. (1999)
  27. Josling P. Preventing the common cold with a garlic supplement: a double-blind, placebo-controlled survey. Adv Ther. (2001)
  28. Andrianova IV, et al. Effect of long-acting garlic tablets "allicor" on the incidence of acute respiratory viral infections in children. Ter Arkh. (2003)
  29. Ishikawa H, et al. Aged garlic extract prevents a decline of NK cell number and activity in patients with advanced cancer. J Nutr. (2006)
  30. Nantz MP, et al. Supplementation with aged garlic extract improves both NK and γδ-T cell function and reduces the severity of cold and flu symptoms: a randomized, double-blind, placebo-controlled nutrition intervention. Clin Nutr. (2012)
  31. Breithaupt-Grögler K, et al. Protective effect of chronic garlic intake on elastic properties of aorta in the elderly. Circulation. (1997)
  32. Galduróz JC, Antunes HK, Santos RF. Gender- and age-related variations in blood viscosity in normal volunteers: a study of the effects of extract of Allium sativum and Ginkgo biloba. Phytomedicine. (2007)
  33. Avci A, et al. Effects of garlic consumption on plasma and erythrocyte antioxidant parameters in elderly subjects. Gerontology. (2008)
  34. Phelps S, Harris WS. Garlic supplementation and lipoprotein oxidation susceptibility. Lipids. (1993)
  35. Simons LA, et al. On the effect of garlic on plasma lipids and lipoproteins in mild hypercholesterolaemia. Atherosclerosis. (1995)
  36. McNulty CA, et al. A pilot study to determine the effectiveness of garlic oil capsules in the treatment of dyspeptic patients with Helicobacter pylori. Helicobacter. (2001)
  37. Graham DY, Anderson SY, Lang T. Garlic or jalapeño peppers for treatment of Helicobacter pylori infection. Am J Gastroenterol. (1999)
  38. Tilli CM, et al. The garlic-derived organosulfur component ajoene decreases basal cell carcinoma tumor size by inducing apoptosis. Arch Dermatol Res. (2003)
  39. Kianoush S, et al. Comparison of therapeutic effects of garlic and d-Penicillamine in patients with chronic occupational lead poisoning. Basic Clin Pharmacol Toxicol. (2012)
  40. Sobenin IA, et al. The effects of time-released garlic powder tablets on multifunctional cardiovascular risk in patients with coronary artery disease. Lipids Health Dis. (2010)
  41. Ried K, Frank OR, Stocks NP. Aged garlic extract lowers blood pressure in patients with treated but uncontrolled hypertension: a randomised controlled trial. Maturitas. (2010)
  42. De BK, et al. The role of garlic in hepatopulmonary syndrome: a randomized controlled trial. Can J Gastroenterol. (2010)
  43. Ashraf R, et al. Effects of Allium sativum (Garlic) on systolic and diastolic blood pressure in patients with essential hypertension. Pak J Pharm Sci. (2013)

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