Triglycerides is a term used to refer to the circulating levels of fatty acids (similar in structure to dietary fatty acids, and Fat Mass) that can be measured via a blood test. Although crucial for energy usage, excessively high circulating Triglycerides is a risk factor for circulatory problems
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Triglycerides
| Grade | Level of Evidence |
|---|---|
| A | Robust research conducted with repeated double blind clinical trials |
| B | Multiple studies where at least two are double-blind and placebo controlled |
| C | Single double blind study or multiple cohort studies |
| D | Uncontrolled or observational studies only |
| Level of Evidence | Supplement | Change | Magnitude of Effect Size | Scientific Consensus | Comments |
|---|---|---|---|---|---|
| A | Fish Oil |  Strong | Fish oil, both EPA and DHA, are reference drugs for the purpose of reducing triglycerides with highly reliable reductions in the range of 15-30% (higher reductions seen... show | ||
| B | Dehydroepiandrosterone | Mixed evidence, but it seems that DHEA doesn't have a significant influence on triglycerides | |||
| B | Conjugated Linoleic Acid |  Minor | May possible increase triglycerides, but is unreliable in doing so and not overly potent. | ||
| B | Policosanol | When excluding older cuban studies (which are highly suspicious) there is no evidence to support a reduction of triglycerides. | |||
| B | Spirulina | Uncertain influences on triglycerides, which appear to be highly context dependent. No study suggests that the changes are overly remarkable in magnitude, but this may... show | |||
| B | Magnesium | For the most part, no significant influence of magnesium supplementation on triglycerides | |||
| B | Berberine | Minor | 100% See 2 studies | Degree of reduction according to meta-analysis was −0.48mmol/L (95% CI −0.57 to −0.39) which was not overly remarkable. | |
| B | Psyllium | Currently, it does not seem like there is a significant influence of psyllium on circulating triglycerides | |||
| B | Olive leaf extract | The majority of the evidence suggests that there is no impressive effect on triglycerides with olive phenolic consumption | |||
| B | Grape Seed Extract | No significant influence of grape seed extract on triglycerides even in a high risk population at a high oral intake of GSE (600mg) | |||
| C | Fenugreek | Minor | 100% See study | May reduce triglyceride levels | |
| C | Ephedrine | Minor | 100% See 2 studies | There appears to be a decrease in triglycerides over time with ephedrine ingestion, which may be due to either the fat burning effects of ephedrine or the weight loss that... show | |
| C | Ginger | Minor | 100% See study | May decrease triglycerides | |
| C | Curcumin | Minor | Some reducing effects have been noted, but they seem to be unreliable and not overly potent | ||
| C | Black Cohosh | 100% See 2 studies | No significant effect on triglyceride concentrations in serum | ||
| C | Punicic Acid | Minor | A possible slight reduction in triglycerides has been noted with pomegranate oil, but this appears to be unreliable | ||
| C | Whey Protein | Minor | 100% See 2 studies | Possible reductions in triglycerides, but it is not sure if this is exclusive to whey protein or due to protein in general. | |
| C | Melatonin | Minor | A possible reduction in triglycerides to a minor degree is noted with melatonin supplementation, but this is not reliable | ||
| C | Vanadium | Minor | 100% See 2 studies | A slight increase in triglycerides has been noted with vanadium supplementation | |
| C | Artichoke Extract | The two better controlled trials noted no change, whereas a decrease and increase has been noted. Unclear overall effects on triglycerides | |||
| C | Licorice | 100% See study | No significant influence on triglycerides | ||
| C | Gynostemma Pentaphyllum | 100% See study | No significant alterations in triglycerides noted with supplementation | ||
| C | Hibiscus Sabdariffa | Notable | Mixed effects on triglycerides, but the lone study that noted a decrease noted comparable potency to pravastatin; requires more literature | ||
| C | Green Coffee Extract | 100% See study | No significant influence on triglycerides following oral intake | ||
| C | Hemp Protein | 100% See 2 studies | No significant influence of oral hemp seeds on triglycerides | ||
| C | Nattokinase | 100% See study | No significant influence on triglycerides | ||
| C | Eleutherococcus senticosus | 100% See study | No significant influences yet known for triglycerides | ||
| C | Benfotiamine | 100% See study | No significant influence on triglycerides. | ||
| C | Cissus Quadrangularis | Minor | 100% See study | Reduction in triglycerides is not overly potent | |
| C | Caffeine | 100% See study | No significant influence on triglyceride levels | ||
| C | Stevia | 100% See study | No significant influence on circulating triglycerides has been noted with stevia consumption | ||
| C | Resveratrol | Minor | 100% See study | A decrease in triglycerides has been noted with resveratrol supplementation | |
| C | Shilajit | Minor | 100% See study | Minor decrease in triglycerides has been noted with shilajit | |
| C | Theaflavins | 100% See study | No significant influence of theaflavins on triglycerides (hypercholesterolemic persons) | ||
| C | Ecklonia Cava | 100% See study | No significant influence on triglycerides noted with ecklonia cava | ||
| C | Ecdysteroids | 100% See study | No significant influence on triglycerides | ||
| C | Salvia hispanica | 100% See 2 studies | No significant influence on triglycerides | ||
| C | Fucoxanthin | Minor | 100% See study | A decrease in circulating triglycerides is noted with fucoxanthine | |
| C | Gamma Oryzanol | 100% See study | No significant alterations in plasma triglycerides seen with supplementation | ||
| C | Garcinia Cambogia | 100% See study | No detectable influence on triglyceride levels | ||
| C | Ganoderma Lucidum | Minor | There may be a small decrease in triglycerides (8% or so) in unhealthy persons, but this has not been observed in otherwise healthy individuals | ||
| C | Green Tea Catechins | 100% See study | No apparent influence on triglycerides | ||
| C | Japanese Knotweed | 100% See study | No significant influence of Japanese Knotweed on triglycerides | ||
| C | Irvingia Gabonensis | Minor | 100% See study | A decrease in triglycerides has been noted, confounded with weight loss | |
| C | L-Carnitine | 100% See study | No significant influence on triglycerides | ||
| C | Microlactin | 100% See study | No significant influence on fasting triglycerides noted | ||
| C | Vitamin C | 100% See 2 studies | No significant influence on fasting or postprandial triglycerides seems apparent with Vitamin C | ||
| C | Vitamin D | Minor | 100% See study | The decrease in triglycerides is present after long term ingestion of Vitamin D, although it isn't to a highly significant degree | |
| C | Soy lecithin | 100% See study | No significant influence on triglycerides | ||
| C | Royal Jelly | Although there may be a reduction in triglycerides associated with Royal Jelly, currently the best evidence suggests no such change | |||
| C | Guggul | 100% See 2 studies | No significant influence of Guggul on triglycerides is detectable | ||
| C | Tetradecyl Thioacetic Acid | Notable | 100% See study | The one trial using TTA to reduce triglycerides noted a reduction of around 15%, which is notable and requires replication | |
| C | Panax Ginseng | 100% See 2 studies | No significant alterations in triglycerides and fatty acids in the fasted state or during exercise | ||
| C | Phosphatidylserine | 100% See study | No significant influence on triglycerides seen at rest or during exercise with PS supplementation | ||
| C | Krill Oil | Minor | 100% See 2 studies | A decrease in triglycerides has been noted with krill oil | |
| C | Lactobacillus casei | ||||
| D | Coconut Oil | 100% See study | Insufficient evidence to support changes in serum triglycerides. | ||
| D | Aronia Melanocarpa | Minor | 100% See study | Requires more studies before conclusions can be made, appears to simply be exerting anti-oxidant effects. | |
| D | Ashwagandha | Minor | 100% See study | A slight decrease in triglycerides has been noted with ashwagandha. | |
| D | Eclipta Alba | Minor | 100% See study | Decreases in triglycerides have been noted, but not to a remarkable degree | |
| D | HMB | 100% See study | No significant influence on triglycerides | ||
| D | Pycnogenol | 100% See study | No significant alterations on triglycerides | ||
| D | Safflower Oil | 100% See study | No significant alterations in triglyceride concentrations |
(Common phrases used by users for this page include omega-3 fatty acids and hypertriglyceridemia in hiv-infected subjects on antiretroviral therapy: systematic review and meta-analysis., lipid lowering effect of ginger on ovaries polycystic, effect of fish oil supplementation on serum triglycerides, ldl cholesterol and ldl subfractions in hypertriglyceridemic adults, bernstein et al. journal of nutrition 2012 docosahexaenoic acid)
(Users who contributed to this page include KurtisFrank)
