Treatment of PCOS

   

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    Scientific Information on Treatment of PCOS

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    The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Treatment of PCOS
    GradeLevel of Evidence
    ARobust research conducted with repeated double blind clinical trials
    BMultiple studies where at least two are double-blind and placebo controlled
    CSingle double blind study or multiple cohort studies
    DUncontrolled or observational studies only
    Level of Evidence
    SupplementChange
    Magnitude of Effect Size
    Scientific ConsensusComments
    AInositol
    Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

    All information is still available and viewable on their respective supplement page.

    References

    1. Benjamin J, et al. Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder. J Psychiatr Res. (1997)
    2. Palatnik A, et al. Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder. J Clin Psychopharmacol. (2001)
    3. Benjamin J, et al. Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder. Am J Psychiatry. (1995)
    4. Fux M, et al. Inositol treatment of obsessive-compulsive disorder. Am J Psychiatry. (1996)
    5. Chengappa KN, et al. Inositol as an add-on treatment for bipolar depression. Bipolar Disord. (2000)
    6. Nierenberg AA, et al. Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone. Am J Psychiatry. (2006)
    7. Levine J, et al. Double-blind, controlled trial of inositol treatment of depression. Am J Psychiatry. (1995)
    8. Nordio M, Proietti E. The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone. Eur Rev Med Pharmacol Sci. (2012)
    9. Donà G, et al. Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome. Eur J Endocrinol. (2012)
    10. Gerli S, Mignosa M, Di Renzo GC. Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial. Eur Rev Med Pharmacol Sci. (2003)
    11. Raffone E, Rizzo P, Benedetto V. Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women. Gynecol Endocrinol. (2010)
    12. Costantino D, et al. Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial. Eur Rev Med Pharmacol Sci. (2009)
    13. Genazzani AD, et al. Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Gynecol Endocrinol. (2012)
    14. Lisi F, et al. Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study. Reprod Biol Endocrinol. (2012)
    15. Genazzani AD, et al. Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome. Gynecol Endocrinol. (2008)
    16. Papaleo E, et al. Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction. Gynecol Endocrinol. (2007)
    17. Gerli S, et al. Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS. Eur Rev Med Pharmacol Sci. (2007)
    18. D'Anna R, et al. Myo-inositol may prevent gestational diabetes in PCOS women. Gynecol Endocrinol. (2012)
    19. Corrado F, et al. The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Diabet Med. (2011)
    20. Ciotta L, et al. Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial. Eur Rev Med Pharmacol Sci. (2011)
    21. Zacchè MM, et al. Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome. Gynecol Endocrinol. (2009)
    22. Santamaria A, et al. One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome. Climacteric. (2012)
    23. Unfer V, et al. Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Eur Rev Med Pharmacol Sci. (2011)
    24. Minozzi M, D'Andrea G, Unfer V. Treatment of hirsutism with myo-inositol: a prospective clinical study. Reprod Biomed Online. (2008)
    25. Iuorno MJ, et al. Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome. Endocr Pract. (2002)
    26. Gianfranco C, et al. Myo-inositol in the treatment of premenstrual dysphoric disorder. Hum Psychopharmacol. (2011)
    27. Salloway S, et al. A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. (2011)
    28. Maeba R, et al. Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome. J Nutr Sci Vitaminol (Tokyo). (2008)
    29. Papaleo E, et al. Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial. Fertil Steril. (2009)
    30. Lam S, et al. A phase I study of myo-inositol for lung cancer chemoprevention. Cancer Epidemiol Biomarkers Prev. (2006)
    31. Levine J, et al. Lack of effect of inositol treatment in chronic schizophrenia. Biol Psychiatry. (1993)
    32. Levine J, et al. Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans. J Psychiatr Res. (1995)
    33. Nemets B, et al. Inositol addition does not improve depression in SSRI treatment failures. J Neural Transm. (1999)
    34. Levine J, et al. CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia. Eur Neuropsychopharmacol. (1994)
    35. Gelber D, Levine J, Belmaker RH. Effect of inositol on bulimia nervosa and binge eating. Int J Eat Disord. (2001)
    36. Nemets B, et al. Myo-inositol has no beneficial effect on premenstrual dysphoric disorder. World J Biol Psychiatry. (2002)
    37. Levine J, et al. Inositol treatment of autism. J Neural Transm. (1997)
    38. Kaplan Z, et al. Inositol treatment of post-traumatic stress disorder. Anxiety. (1996)
    39. Barak Y, et al. Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial. Prog Neuropsychopharmacol Biol Psychiatry. (1996)
    40. Allan SJ, et al. The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial. Br J Dermatol. (2004)

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