Total Cholesterol

Total Cholesterol is a phrase used to refer to all circulating cholesterol molecules, and is totalled by adding LDL-C, HDL-C and vLDL-C together. It is distinct from Triglycerides.

   
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Total Cholesterol
GradeLevel of Evidence
ARobust research conducted with repeated double blind clinical trials
BMultiple studies where at least two are double-blind and placebo controlled
CSingle double blind study or multiple cohort studies
DUncontrolled or observational studies only
Level of Evidence
SupplementChange
Magnitude of Effect Size
Scientific ConsensusComments
APolicosanol
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
AFish Oil
AGarlic
ARed Clover Extract
AChromium
ACocoa Extract
BCreatine
BL-Carnitine
BCurcumin
BSpirulina
BBerberine
BPsyllium
BOlive leaf extract
BGrape Seed Extract
BRoyal Jelly
BNigella sativa
BHesperidin
BTrimethylglycine
BAstaxanthin
BVitamin E
BLactobacillus reuteri
CECA
CGinger
CCoenzyme Q10
CVitamin C
CPunicic Acid
CWhey Protein
CGrapefruit
CVanadium
CArtichoke Extract
CLicorice
CGreen Coffee Extract
CNattokinase
CEleutherococcus senticosus
CBenfotiamine
CCissus quadrangularis
CAshwagandha
CStevia
CTheaflavins
CEcklonia cava
CEcdysteroids
CSalvia hispanica
CGamma Oryzanol
CGarcinia cambogia
CGanoderma lucidum
CGreen Tea Catechins
CHibiscus sabdariffa
CHMB
CJapanese Knotweed
CIrvingia gabonensis
CMagnesium
CMelatonin
CMicrolactin
CSoy lecithin
CResveratrol
CPyruvate
CGuggul
CTetradecyl Thioacetic Acid
CPanax ginseng
CPhosphatidylserine
CKrill Oil
CLactobacillus casei
CCitrulline
CVitamin K
CSea Buckthorn
CBlueberry
CDehydroepiandrosterone
CZinc
CInositol
CTribulus terrestris
CRooibos
CAnethum graveolens
CCitrullus colocynthis
CPhosphatidylcholine
CYacon
CRose Hip
CPterostilbene
CVitamin B3
DCoffee
DQuercetin
DTauroursodeoxycholic Acid
DPueraria lobata
DCoconut Oil
DAronia melanocarpa
DYerba mate
DEclipta alba
DPycnogenol
DEmblica officinalis
DRubus coreanus
DPerilla Oil
DRuscus aculeatus
DColostrum

References

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  2. Otto W1, et al. Randomized control trials using a tablet formulation of hyperimmune bovine colostrum to prevent diarrhea caused by enterotoxigenic Escherichia coli in volunteers. Scand J Gastroenterol. (2011)
  3. Marchbank T1, et al. The nutriceutical bovine colostrum truncates the increase in gut permeability caused by heavy exercise in athletes. Am J Physiol Gastrointest Liver Physiol. (2011)
  4. Buckley JD1, et al. Bovine colostrum supplementation during running training increases intestinal permeability. Nutrients. (2009)
  5. Mero A1, et al. IGF-I, IgA, and IgG responses to bovine colostrum supplementation during training. J Appl Physiol (1985). (2002)
  6. Mero A1, et al. Effects of bovine colostrum supplementation on serum IGF-I, IgG, hormone, and saliva IgA during training. J Appl Physiol (1985). (1997)
  7. Wolvers DA1, et al. Effect of a mixture of micronutrients, but not of bovine colostrum concentrate, on immune function parameters in healthy volunteers: a randomized placebo-controlled study. Nutr J. (2006)
  8. Shing CM1, et al. Effects of bovine colostrum supplementation on immune variables in highly trained cyclists. J Appl Physiol (1985). (2007)
  9. Shing CM1, et al. The influence of bovine colostrum supplementation on exercise performance in highly trained cyclists. Br J Sports Med. (2006)
  10. Khan Z1, et al. Use of the 'nutriceutical', bovine colostrum, for the treatment of distal colitis: results from an initial study. Aliment Pharmacol Ther. (2002)
  11. Playford RJ1, et al. Co-administration of the health food supplement, bovine colostrum, reduces the acute non-steroidal anti-inflammatory drug-induced increase in intestinal permeability. Clin Sci (Lond). (2001)
  12. Jensen GS1, Patel D, Benson KF. A novel extract from bovine colostrum whey supports innate immune functions. II. Rapid changes in cellular immune function in humans. Prev Med. (2012)
  13. Patıroğlu T1, Kondolot M. The effect of bovine colostrum on viral upper respiratory tract infections in children with immunoglobulin A deficiency. Clin Respir J. (2013)
  14. Hofman Z1, et al. The effect of bovine colostrum supplementation on exercise performance in elite field hockey players. Int J Sport Nutr Exerc Metab. (2002)
  15. Brinkworth GD1, et al. Effect of bovine colostrum supplementation on the composition of resistance trained and untrained limbs in healthy young men. Eur J Appl Physiol. (2004)
  16. Brinkworth GD1, Buckley JD. Concentrated bovine colostrum protein supplementation reduces the incidence of self-reported symptoms of upper respiratory tract infection in adult males. Eur J Nutr. (2003)
  17. Crooks C1, et al. Effect of bovine colostrum supplementation on respiratory tract mucosal defenses in swimmers. Int J Sport Nutr Exerc Metab. (2010)
  18. Carol A1, et al. Bovine colostrum supplementation's lack of effect on immune variables during short-term intense exercise in well-trained athletes. Int J Sport Nutr Exerc Metab. (2011)
  19. Brinkworth GD1, Buckley JD. Bovine colostrum supplementation does not affect plasma buffer capacity or haemoglobin content in elite female rowers. Eur J Appl Physiol. (2004)
  20. Lindbaek M1, et al. Do colostrum tablets have a symptomatic effect on sore throat?. Tidsskr Nor Laegeforen. (2004)
  21. Crooks CV1, et al. The effect of bovine colostrum supplementation on salivary IgA in distance runners. Int J Sport Nutr Exerc Metab. (2006)
  22. Coombes JS1, et al. Dose effects of oral bovine colostrum on physical work capacity in cyclists. Med Sci Sports Exerc. (2002)
  23. Antonio J1, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. (2001)
  24. Buckley JD1, Brinkworth GD, Abbott MJ. Effect of bovine colostrum on anaerobic exercise performance and plasma insulin-like growth factor I. J Sports Sci. (2003)
  25. Florén CH1, et al. ColoPlus, a new product based on bovine colostrum, alleviates HIV-associated diarrhoea. Scand J Gastroenterol. (2006)
  26. Greenberg PD1, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol. (1996)
  27. Rump JA1, et al. Treatment of diarrhoea in human immunodeficiency virus-infected patients with immunoglobulins from bovine colostrum. Clin Investig. (1992)
  28. Brinkworth GD1, et al. Oral bovine colostrum supplementation enhances buffer capacity but not rowing performance in elite female rowers. Int J Sport Nutr Exerc Metab. (2002)
  29. Buckley JD1, et al. Bovine colostrum supplementation during endurance running training improves recovery, but not performance. J Sci Med Sport. (2002)
  30. Shing CM1, et al. A pilot study: bovine colostrum supplementation and hormonal and autonomic responses to competitive cycling. J Sports Med Phys Fitness. (2013)
  31. He F1, et al. Modulation of human humoral immune response through orally administered bovine colostrum. FEMS Immunol Med Microbiol. (2001)
  32. Lund P1, et al. Randomised controlled trial of colostrum to improve intestinal function in patients with short bowel syndrome. Eur J Clin Nutr. (2012)
  33. Tacket CO1, et al. Protection by milk immunoglobulin concentrate against oral challenge with enterotoxigenic Escherichia coli. N Engl J Med. (1988)
  34. Tacket CO1, et al. Lack of prophylactic efficacy of an enteric-coated bovine hyperimmune milk product against enterotoxigenic Escherichia coli challenge administered during a standard meal. J Infect Dis. (1999)
  35. Kim JH1, et al. Health-promoting effects of bovine colostrum in Type 2 diabetic patients can reduce blood glucose, cholesterol, triglyceride and ketones. J Nutr Biochem. (2009)
  36. Mero A1, et al. Protein metabolism and strength performance after bovine colostrum supplementation. Amino Acids. (2005)
  37. Kaducu FO1, et al. Effect of bovine colostrum-based food supplement in the treatment of HIV-associated diarrhea in Northern Uganda: a randomized controlled trial. Indian J Gastroenterol. (2011)

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