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Symptoms of Osteoarthritis

   

Table of Contents

    Summary (All Essential Benefits/Effects/Facts & Information)

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    Scientific Information on Symptoms of Osteoarthritis

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    Human Effect Matrix

    The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Symptoms of Osteoarthritis
    GradeLevel of Evidence
    ARobust research conducted with repeated double blind clinical trials
    BMultiple studies where at least two are double-blind and placebo controlled
    CSingle double blind study or multiple cohort studies
    DUncontrolled or observational studies only
    Level of Evidence
    		SupplementChange
    		Magnitude of Effect Size
    		Scientific ConsensusComments
    AGlucosamine

    Minor

    There appears to be a small decrease in osteoarthritis symptoms associated with glucosamine (as sulfate, not hydrochloride) which is somewhat unreliable but consistently... show

    BGinger

    Minor

    There may be a small reducing effect, but it does not appear to be greater than the active control of Ibuprofen

    BBoswellia Serrata

    Notable

    The reduction observed with Boswellia serrata for pain and other symptoms of osteoarthritis are more profound than other supplements including that of glucosamine (reference),... show

    BS-Adenosyl Methionine

    Notable

    Decreases in symptoms of osteroarthritis appear to be reduced to similar levels with SAMe as with pharmaceuticals like Naproxen, although SAMe requires a longer period... show

    CCurcumin

    Minor

    Possible reductions in osteoarthritic symptoms associated with curcumin ingestion

    CCreatine

    Minor

    Appeared to increase functionality, although not to a remarkable degree.

    CStinging Nettle

    Highly difficult to assess the efficacy of stinging nettle on osteoarthritic symptoms due to a wide degree of variance in study methodology

    CFeverfew

    No significant interaction between supplemental Feverfew and osteoarthritic symptoms

    CBromelain

    No significant influence on symptoms of osteoarthritis when tested

    CMicrolactin

    Minor

    Appears to reduce pain symptoms and improve functionality associated with osteoarthritis, with one study suggesting comparable efficacy to Glucosamine sulfate

    CMethylsulfonylmethane

    Minor

    A decrease in symptoms of osteoarthritis has been noted and seems to be somewhat comparable in potency to Glucosamine sulfate

    DVitamin C

    No significant influence on the symptoms of osteoarthritis

    DGuggul

    Minor

    Possible reductions in the symptoms associated with osteoarthritis

    DHarpagophytum Procumbens

    Minor

    Symptoms of osteoarthritis appear to be reduced following ingestion of devil's claw, but insufficient robust evidence exists

    Scientific Support & Reference Citations

    References

    1. Medici V, et al. S-adenosyl-L-methionine treatment for alcoholic liver disease: a double-blinded, randomized, placebo-controlled trial. Alcohol Clin Exp Res. (2011)
    2. Levkovitz Y, et al. Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder. J Affect Disord. (2012)
    3. Feld JJ, et al. S-adenosyl methionine improves early viral responses and interferon-stimulated gene induction in hepatitis C nonresponders. Gastroenterology. (2011)
    4. Papakostas GI, et al. S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial. Am J Psychiatry. (2010)
    5. Kim J, et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther. (2009)
    6. Caruso I, Pietrogrande V. Italian double-blind multicenter study comparing S-adenosylmethionine, naproxen, and placebo in the treatment of degenerative joint disease. Am J Med. (1987)
    7. Najm WI, et al. S-adenosyl methionine (SAMe) versus celecoxib for the treatment of osteoarthritis symptoms: a double-blind cross-over trial. ISRCTN36233495. BMC Musculoskelet Disord. (2004)
    8. Soeken KL, et al. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J Fam Pract. (2002)
    9. Thompson MA, et al. Dietary supplement S-adenosyl-L-methionine (AdoMet) effects on plasma homocysteine levels in healthy human subjects: a double-blind, placebo-controlled, randomized clinical trial. J Altern Complement Med. (2009)
    10. Loehrer FM, et al. Influence of oral S-adenosylmethionine on plasma 5-methyltetrahydrofolate, S-adenosylhomocysteine, homocysteine and methionine in healthy humans. J Pharmacol Exp Ther. (1997)
    11. Gören JL, et al. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy. (2004)
    12. Binder T, et al. Randomized prospective comparative study of ursodeoxycholic acid and S-adenosyl-L-methionine in the treatment of intrahepatic cholestasis of pregnancy. J Perinat Med. (2006)
    13. Arnold O, et al. Double-blind, placebo-controlled pharmacodynamic studies with a nutraceutical and a pharmaceutical dose of ademetionine (SAMe) in elderly subjects, utilizing EEG mapping and psychometry. Eur Neuropsychopharmacol. (2005)
    14. Santini D, et al. S-adenosylmethionine (AdoMet) supplementation for treatment of chemotherapy-induced liver injury. Anticancer Res. (2003)
    15. Jacobsen S, Danneskiold-Samsøe B, Andersen RB. Oral S-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation. Scand J Rheumatol. (1991)
    16. Di Rocco A, et al. S-Adenosyl-Methionine improves depression in patients with Parkinson's disease in an open-label clinical trial. Mov Disord. (2000)

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