Symptoms of Osteoarthritis

Symptoms of osteoarthritis (OA) tend to reflect mobility, joint pain and stiffness, as well as quality of life in persons with OA. Supplements that benefit these symptoms according to self-reported rating scales are prophylactic.

This page features 15 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Symptoms of Osteoarthritis
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Glucosamine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Boswellia serrata
B S-Adenosyl Methionine
B Ginger
B Rose Hip
C Curcumin
C Pycnogenol
C Creatine
C Methylsulfonylmethane
C Microlactin
C Bromelain
C Feverfew
C Stinging Nettle
C Type II Collagen
C Vitamin D
D Guggul
D Harpagophytum procumbens
D Vitamin C


  1. Acute antioxidant supplementation improves endurance performance in trained athletes
  2. Stanislavov R, Nikolova V Treatment of erectile dysfunction with pycnogenol and L-arginine . J Sex Marital Ther. (2003)
  3. Enseleit F, et al Effects of Pycnogenol on endothelial function in patients with stable coronary artery disease: a double-blind, randomized, placebo-controlled, cross-over study . Eur Heart J. (2012)
  4. Errichi S, et al Supplementation with Pycnogenol® improves signs and symptoms of menopausal transition . Panminerva Med. (2011)
  5. Luzzi R, et al Pycnogenol® supplementation improves cognitive function, attention and mental performance in students . Panminerva Med. (2011)
  6. Marini A, et al Pycnogenol® effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women . Skin Pharmacol Physiol. (2012)
  7. Belcaro G, et al Pycnogenol® improvements in asthma management . Panminerva Med. (2011)
  8. Devaraj S, et al Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile . Lipids. (2002)
  9. Koch R Comparative study of Venostasin and Pycnogenol in chronic venous insufficiency . Phytother Res. (2002)
  10. Nishioka K, et al Pycnogenol, French maritime pine bark extract, augments endothelium-dependent vasodilation in humans . Hypertens Res. (2007)
  11. Liu X, et al Pycnogenol, French maritime pine bark extract, improves endothelial function of hypertensive patients . Life Sci. (2004)
  12. Belcaro G, et al Treatment of osteoarthritis with Pycnogenol. The SVOS (San Valentino Osteo-arthrosis Study). Evaluation of signs, symptoms, physical performance and vascular aspects . Phytother Res. (2008)
  13. Hosseini S, et al Pycnogenol((R)) in the Management of Asthma . J Med Food. (2001)
  14. Zibadi S1, et al Reduction of cardiovascular risk factors in subjects with type 2 diabetes by Pycnogenol supplementation . Nutr Res. (2008)
  15. Liu X, Zhou HJ, Rohdewald P French maritime pine bark extract Pycnogenol dose-dependently lowers glucose in type 2 diabetic patients . Diabetes Care. (2004)

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