Symptoms of Osteoarthritis

Symptoms of osteoarthritis (OA) tend to reflect mobility, joint pain and stiffness, as well as quality of life in persons with OA. Supplements that benefit these symptoms according to self-reported rating scales are prophylactic.

This page features 7 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Symptoms of Osteoarthritis
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Glucosamine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
B Boswellia serrata
B S-Adenosyl Methionine
B Ginger
B Rose Hip
C Curcumin
C Pycnogenol
C Creatine
C Methylsulfonylmethane
C Microlactin
C Bromelain
C Feverfew
C Stinging Nettle
C Type II Collagen
C Vitamin D
D Guggul
D Harpagophytum procumbens
D Vitamin C


  1. Adam M1, et al Postmenopausal osteoporosis. Treatment with calcitonin and a diet rich in collagen proteins . Cas Lek Cesk. (1996)
  2. Schwartz SR1, Park J Ingestion of BioCell Collagen(®), a novel hydrolyzed chicken sternal cartilage extract; enhanced blood microcirculation and reduced facial aging signs . Clin Interv Aging. (2012)
  3. Trentham DE1, et al Effects of oral administration of type II collagen on rheumatoid arthritis . Science. (1993)
  4. Lugo JP, et al Undenatured type II collagen (UC-II®) for joint support: a randomized, double-blind, placebo-controlled study in healthy volunteers . J Int Soc Sports Nutr. (2013)
  5. Crowley DC1, et al Safety and efficacy of undenatured type II collagen in the treatment of osteoarthritis of the knee: a clinical trial . Int J Med Sci. (2009)
  6. Barnett ML1, et al Treatment of rheumatoid arthritis with oral type II collagen. Results of a multicenter, double-blind, placebo-controlled trial . Arthritis Rheum. (1998)
  7. Barnett ML1, Combitchi D, Trentham DE A pilot trial of oral type II collagen in the treatment of juvenile rheumatoid arthritis . Arthritis Rheum. (1996)

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