The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Subjective Well-Being
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Supplement||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
Unreliable and not overly potent.
No significant influence on well being is noted with DHEA per se, although it may come secondary to other changes occurring during DHEA supplementation (such as improved... show
The increase in well being appears to be quite large, but secondary to reducing anxiety. At least one study has noted that, in healthy persons subject to a minor stressor... show
There appears to be an increase in well being and happiness in persons who either have a disease state treated (ie, better glycemic control in diabetes or less erectile... show
Increases in subjective well being and contentment in fatigued or stressed individuals appears to be greater than other supplements.
Subjective well being increases in disease states where other symptoms (seen as adverse) are decreased; an inherent increase of well being is uncertain.
|C||Green Tea Catechins|
An increase in well being has been noted in unhealthy persons given green tea catechins
Chlorogenic acid may have a mood enhancing effect independent of caffeine
No significant changes in subjective well being associated with carnitine intake
Appears to increase well being acutely following the first doses of ephedrine, secondary to the psychostimulatory effects
An improvement in mood has been noted in hospitalized persons
|C||Conjugated Linoleic Acid|
Insufficient evidence to support an inherent contentment boosting effect, as the lone study was confounded with weight loss.
See 2 studies
May increase subjective well being and mood state, possibly secondary to reducing fatigue or from catecholamines
There appears to be an increase in subjective well being during stress when tyrosine is preloaded (perhaps secondary to the antistress effects of tyrosine), although this... show
An increase in well being has been noted
An increase in well being has been noted to be secondary to a reduction in cortisol
An increase in well being may occur secondary to weight loss, although due to the complications in weight loss with pyruvate this may not be feasible
An increase in well being and mood has been noted in students undergoing academic testing, which correlated with improved test scores
No significant influence on subjective well being and mood state per se
No significant influence on subjective well being noted
An improvement in well being has been noted in nondepressed and nonelderly obese persons given fish oil supplementation to a small magnitude.
In persons with peripheral artery disease (intermittent claudication), despite improving symptoms as assessed by a treadmill walking test there does not appear to be an... show
May increase well being in those with menopause if a reduction of symptoms occurs.
Increase in well-being was likely secondary to reducing joint pain from osteoarthritis
Minor improvements in well being secondary to reducing joint pain
An increase in well being has been noted with lavender aromatherapy, possible secondary to the relaxing effects
See 2 studies
An increase in well being has been noted to be secondary to the reduced rate of cognitive decline
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