Range of Motion

Scientific Information on Range of Motion

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Range of Motion

Level of Evidence	Supplement	Change	Magnitude of Effect Size	Scientific Consensus	Comments
C	HMB			100% See study	No significant influence on range of motion (impaired in both groups due to soreness post workout)
C	Glucosamine		Minor	100% See study	An increase in range of motion has been noted alongside general osteoarthritis symptom reduction
D	Creatine		Minor	100% See study	One study noting a reduction in range of motion with creatine supplementation, needs to be replicated.

References

1. Ostojic SM, et al. Glucosamine administration in athletes: effects on recovery of acute knee injury. Res Sports Med. (2007)
2. Chopra A, et al. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford). (2013)
3. Yoshimura M, et al. Evaluation of the effect of glucosamine administration on biomarkers for cartilage and bone metabolism in soccer players. Int J Mol Med. (2009)
4. Momomura R, et al. Evaluation of the effect of glucosamine administration on biomarkers of cartilage and bone metabolism in bicycle racers. Mol Med Report. (2013)
5. Wilkens P, et al. Effect of glucosamine on pain-related disability in patients with chronic low back pain and degenerative lumbar osteoarthritis: a randomized controlled trial. JAMA. (2010)
6. Herrero-Beaumont G, et al. Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator. Arthritis Rheum. (2007)
7. Reginster JY, et al. Long-term effects of glucosamine sulphate on osteoarthritis progression: a randomised, placebo-controlled clinical trial. Lancet. (2001)
8. Pavelká K, et al. Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study. Arch Intern Med. (2002)
9. Noack W, et al. Glucosamine sulfate in osteoarthritis of the knee. Osteoarthritis Cartilage. (1994)
10. Yue J, et al. Chondroitin sulfate and/or glucosamine hydrochloride for Kashin-Beck disease: a cluster-randomized, placebo-controlled study. Osteoarthritis Cartilage. (2012)
11. Clegg DO, et al. Glucosamine, chondroitin sulfate, and the two in combination for painful knee osteoarthritis. N Engl J Med. (2006)
12. Liu W, et al. Kashin-Beck disease in Sichuan, China: report of a pilot open therapeutic trial. J Clin Rheumatol. (2012)
13. Wangroongsub Y, et al. Comparable clinical outcomes between glucosamine sulfate-potassium chloride and glucosamine sulfate sodium chloride in patients with mild and moderate knee osteoarthritis: a randomized, double-blind study. J Med Assoc Thai. (2010)
14. Cahlin BJ, Dahlström L. No effect of glucosamine sulfate on osteoarthritis in the temporomandibular joints--a randomized, controlled, short-term study. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. (2011)
15. Thie NM, Prasad NG, Major PW. Evaluation of glucosamine sulfate compared to ibuprofen for the treatment of temporomandibular joint osteoarthritis: a randomized double blind controlled 3 month clinical trial. J Rheumatol. (2001)
16. Vlad SC, et al. Glucosamine for pain in osteoarthritis: why do trial results differ. Arthritis Rheum. (2007)
17. Usha PR, Naidu MU. Randomised, Double-Blind, Parallel, Placebo-Controlled Study of Oral Glucosamine, Methylsulfonylmethane and their Combination in Osteoarthritis. Clin Drug Investig. (2004)
18. Pujalte JM, Llavore EP, Ylescupidez FR. Double-blind clinical evaluation of oral glucosamine sulphate in the basic treatment of osteoarthrosis. Curr Med Res Opin. (1980)
19. McAlindon T, et al. Effectiveness of glucosamine for symptoms of knee osteoarthritis: results from an internet-based randomized double-blind controlled trial. Am J Med. (2004)
20. Rindone JP, et al. Randomized, controlled trial of glucosamine for treating osteoarthritis of the knee. West J Med. (2000)
21. Hughes R, Carr A. A randomized, double-blind, placebo-controlled trial of glucosamine sulphate as an analgesic in osteoarthritis of the knee. Rheumatology (Oxford). (2002)
22. Houpt JB, et al. Effect of glucosamine hydrochloride in the treatment of pain of osteoarthritis of the knee. J Rheumatol. (1999)
23. McAlindon TE, et al. Glucosamine and chondroitin for treatment of osteoarthritis: a systematic quality assessment and meta-analysis. JAMA. (2000)
24. Towheed TE, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. (2001)
25. Towheed TE, et al. Glucosamine therapy for treating osteoarthritis. Cochrane Database Syst Rev. (2005)
26. Wandel S, et al. Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis. BMJ. (2010)
27. Richy F, et al. Structural and symptomatic efficacy of glucosamine and chondroitin in knee osteoarthritis: a comprehensive meta-analysis. Arch Intern Med. (2003)

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