A form of oxidation that influences lipids. In the body, it tends to reflect damage to cell membranes and is assessed by biomarkers thought to represent lipid peroxidation (MDA and TBARS)
The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Lipid Peroxidation
| Grade | Level of Evidence |
|---|---|
| A | Robust research conducted with repeated double blind clinical trials |
| B | Multiple studies where at least two are double-blind and placebo controlled |
| C | Single double blind study or multiple cohort studies |
| D | Uncontrolled or observational studies only |
| Level of Evidence | Supplement | Change | Magnitude of Effect Size | Scientific Consensus | Comments |
|---|---|---|---|---|---|
| B | L-Carnitine |   Minor | The reduction in MDA that occurs during exercise may also occur at rest, suggesting a per se effect | ||
| B | Coenzyme Q10 | Notable | Appears to reduce biomarkers of lipid peroxidation. CoQ10 tends to be a reference drug for lipid peroxidation, and although it is more potent than other nutraceuticals... show | ||
| B | Spirulina | Notable | Although there is no reference drug to compare the effects of Spirulina against, the decrease in lipid peroxidation as assessed by serum MDA is quite notable and is likely... show | ||
| B | Curcumin | Minor | A decrease in lipid peroxidation results following curcumin ingestion chronically | ||
| B | Fish Oil | Minor | Both increases and decreases in lipid peroxidation have been noted with fish oil supplementation, with the increases in peroxidation usually seen with high doses of fish... show | ||
| C | Creatine | Minor | A minor reduction, nothing to a remarkable degree. | ||
| C | Vitamin C | Minor | Mixed and weak influences on lipid peroxidation, but a possible reduction exists | ||
| C | Melatonin | Minor | 100% See study | A reduction in lipid peroxidation has been noted with melatonin | |
| C | Eleutherococcus senticosus | 100% See study | Insufficient evidence to evaluate lipid peroxidation reducing effects | ||
| C | Alpha-Lipoic Acid | Minor | 100% See 2 studies | Appears to reduce biomarkers of lipid peroxidation (MDA mostly) | |
| C | Cissus Quadrangularis | Minor | 100% See study | Decrease noted is not overly remarkable | |
| C | Rhodiola Rosea | 100% See 2 studies | No significant influences on lipid peroxidation biomarkers in serum | ||
| C | Olive leaf extract | Minor | 100% See 2 studies | Appears to reduce biomarkers of lipid peroxidation. | |
| C | Shilajit | Minor | 100% See study | A decrease in lipid peroxidation (assessed by MDA) has been noted in serum and semen following oral ingestion of shilajit | |
| C | Stinging Nettle | 100% See study | No significant effect on lipid peroxidation has been noted. | ||
| C | Ganoderma Lucidum | 100% See 2 studies | No significant changes in lipid peroxidation biomarkers (such as MDA) are present following ingestion of Reishi | ||
| C | Kaempferia Parviflora | Minor | 100% See study | A minor decrease in lipid peroxidation has been noted with supplementation of low doses | |
| C | Licorice | Minor | 100% See 2 studies | A decrease in lipid peroxidation is noted with licorice consumption, not to a remarkable degree | |
| C | Methylsulfonylmethane | Minor | 100% See study | A decrease in exercise-induced lipid peroxidation is noted as assessed by serum MDA | |
| C | Citrulline | 100% See study | No significant influence of citrulline on lipid peroxidation has been noted | ||
| D | Green Tea Catechins | Minor | 100% See study | Can decrease biomarkers of lipid peroxidation | |
| D | Aronia Melanocarpa | Notable | 100% See study | Definitely requires more evidence, but appears to be fairly effective at reducing lipid peroxidation and other oxidative parameters (lone study noting a 40% reduction with aronia) | |
| D | Yerba Mate | Minor | 100% See study | A decrease in lipid peroxidation has been noted with Mate consumption over 7 days | |
| D | Eclipta Alba | Minor | 100% See study | A decrease in biomarkers of lipid peroxidation has been noted, possible related to an increase in serum Vitamin E concentrations | |
| D | Hibiscus Sabdariffa | Minor | 100% See study | Has been noted to reduce lipid peroxidation | |
| D | Melissa officinalis | Minor | 100% See study | A slight decrease in biomarkers of lipid peroxidation occurs following ingestion of lemon balm | |
| D | Punicalagins | Minor | 100% See study | A decrease in lipid peroxidation has been noted | |
| D | Krill Oil | 100% See study | Despite containing PUFAs, no significant changes in lipid peroxidation |
(Common phrases used by users for this page include zembron-lacny a 2009, sport and peroxidation)
(Users who contributed to this page include Sol, conlank, KurtisFrank, herman_gill)
