Lean Mass

Lean Mass is overall body mass after Fat Mass has been subtracted. It consists of organs, bone, the brain, water and contractile muscle; since changes in the first three do not occur often, changes in lean mass are assumed to either be muscle tissue, glycogen (energy storage) or water.

This page features 12 unique references to scientific papers.

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lbm , lean body mass

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Lean Mass
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Conjugated Linoleic Acid
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
A Creatine
B Colostrum
B Whey Protein
B Chromium
B Dehydroepiandrosterone
C Arginine
C Beta-Alanine
C Coleus forskohlii
C L-Carnitine
C Leucic Acid
C Vitamin D
C Arachidonic acid
C D-Aspartic Acid
C Ecdysteroids
C Fenugreek
C Fish Oil
C Glutamine
C Hoodia gordonii
C Leucine
C Licorice
C Punicic Acid
C Tribulus terrestris
C Trimethylglycine
C Ursolic Acid
C Velvet Antler
C Yohimbine
D Eurycoma Longifolia Jack
D Safflower Oil
D Ashwagandha
D Cocoa Extract
D Mangifera indica


  1. Effect of the dietary supplement Meltdown on catecholamine secretion, markers of lipolysis, and metabolic rate in men and women: a randomized, placebo controlled, cross-over study
  2. Meyerbroeker K, et al Does yohimbine hydrochloride facilitate fear extinction in virtual reality treatment of fear of flying? A randomized placebo-controlled trial . Psychother Psychosom. (2012)
  3. Sommer M, et al Psychological and neuroendocrine responses to social stress and to the administration of the alpha-2-receptor antagonist, yohimbine, in highly trained endurance athletes in comparison to untrained healthy controls . Pharmacopsychiatry. (2011)
  4. Ostojic SM Yohimbine: the effects on body composition and exercise performance in soccer players . Res Sports Med. (2006)
  5. Ernst E, Pittler MH Yohimbine for erectile dysfunction: a systematic review and meta-analysis of randomized clinical trials . J Urol. (1998)
  6. Umhau JC, et al Pharmacologically induced alcohol craving in treatment seeking alcoholics correlates with alcoholism severity, but is insensitive to acamprosate . Neuropsychopharmacology. (2011)
  7. Shibao C, et al Comparative efficacy of yohimbine against pyridostigmine for the treatment of orthostatic hypotension in autonomic failure . Hypertension. (2010)
  8. Powers MB, et al Facilitation of fear extinction in phobic participants with a novel cognitive enhancer: a randomized placebo controlled trial of yohimbine augmentation . J Anxiety Disord. (2009)
  9. Cameron OG, et al Effects of yohimbine on cerebral blood flow, symptoms, and physiological functions in humans . Psychosom Med. (2000)
  10. Guay AT, et al Yohimbine treatment of organic erectile dysfunction in a dose-escalation trial . Int J Impot Res. (2002)
  11. Jonderko K, Kucio C Effect of anti-obesity drugs promoting energy expenditure, yohimbine and ephedrine, on gastric emptying in obese patients . Aliment Pharmacol Ther. (1991)
  12. Kennedy SH, et al Melatonin responses to clonidine and yohimbine challenges . J Psychiatry Neurosci. (1995)

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