The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what what supplements affect Lean Mass
|Grade||Level of Evidence|
|A||Robust research conducted with repeated double blind clinical trials|
|B||Multiple studies where at least two are double-blind and placebo controlled|
|C||Single double blind study or multiple cohort studies|
|D||Uncontrolled or observational studies only|
|Level of Evidence ||Supplement||Change||Magnitude of Effect Size ||Scientific Consensus||Comments|
Does appear to have inherent lean mass building properties, but a large amount of research is confounded with water weight gains (difficult to assess potency).
|A||Conjugated Linoleic Acid|
Some evidence that CLA can preserve lean mass during fat loss in an obese cohort of patients, but even in this subgroup the results are highly unreliable.
Perhaps due to a lack of studies pairing DHEA with a prolonged resistance training program, there is no evidence to support DHEA supplementation to increase muscular or lean mass
Protein in general increases lean mass, but there is not a significant body of evidence to support whey protein as being more effective than other protein sources
No significant influences on lean body mass associated with HMB supplementation
See 2 studies
An increase in lean mass has been noted in elderly persons. This may not apply to lean healthy individuals, and no research assesses youth
No significant influence on lean mass detected with yohimbine ingestion
No significant influence on lean mass has been noted with punicic acid supplementation
Doesn't appear overly potent, but either inherently or through greater workload there appears to be a hypertrophic effect associated with beta-alanine.
No significant alterations in lean mass associated with licorice
Somewhat effective (2lbs over 12 weeks relative to placebo) although somewhat confounded with the increase in bone mass, as lean mass is inclusive of bone and skeletal muscle.
No interaction between velvet antler and lean mass accrual
See 2 studies
Insufficient evidence to support an increase of lean mass associated with tribulus relative to placebo during a training program.
No differences between ecdysteroids and placebo in improving lean mass accrual during a weight lifting program
No demonstrated benefit to lean mass accrual in otherwise healthy trained men given a workout program
An increase in lean mass has been noted in dieting obese women relative to control (2,000IU) and a trend to reduce lean mass relative to control has been noted in exercising... show
No significant influence on lean mass associated with fish oil supplementation
An increase in lean mass has been noted in the legs of soccer players to the degree of 0.4kg over 4 weeks; this study currently stands alone
An increase in lean mass has been noted in persons with impaired glucose tolerance using L-arginine over a long period of time, where placebo experienced a decrease. It... show
|D||Eurycoma Longifolia Jack|
One pilot study has noted an increase more than control when both eurycoma and control were paired with exercise
An increase in lean mass relative to control (CLA) has been noted in obese menopausal women
(Common phrases used by users for this page include cache:http://examine.com/supplements/Beta-Alanine/, cache:eFAcSrjhQmEJ:examine.com/supplements/Melatonin/ oxytocin examine.com)