Low Density Lipoprotein (LDL) choleterol is (sometimes falsely) seen as the 'bad' cholesterol and is the ying to HDL-C's yang. LDL serves to bring fatty acids and cholesterol from the liver and circulate them to tissues, oxidized LDL (oLDL) can contribute to heart disease.

This page features 75 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect LDL-C
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Garlic
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
A Cocoa Extract
A Fish Oil
A Policosanol
A Psyllium
A Chromium
A Red Clover Extract
B Vitamin B3
B Berberine
B Green Tea Catechins
B Nigella sativa
B Olive leaf extract
B Spirulina
B Trimethylglycine
B Zinc
B Astaxanthin
B Conjugated Linoleic Acid
B Curcumin
B Dehydroepiandrosterone
B Hesperidin
B L-Carnitine
B Lactobacillus reuteri
B Vitamin E
C Krill Oil
C Soy lecithin
C Artichoke Extract
C Ashwagandha
C Ecklonia cava
C Eleutherococcus senticosus
C Ephedrine
C Ginger
C Grapefruit
C Guggul
C Inositol
C Irvingia gabonensis
C Microlactin
C Panax ginseng
C Pterostilbene
C Pueraria mirifica
C Pycnogenol
C Pyruvate
C Quercetin
C Resveratrol
C Rooibos
C Rose Hip
C Shilajit
C Vitamin D
C Whey Protein
C Yacon
C Anethum graveolens
C Benfotiamine
C Black Cohosh
C Blueberry
C Caffeine
C Citrulline
C Citrullus colocynthis
C Creatine
C Gamma Oryzanol
C Ganoderma lucidum
C Garcinia cambogia
C Grape Seed Extract
C Green Coffee Extract
C Gynostemma pentaphyllum
C Hemp Protein
C Hibiscus sabdariffa
C Japanese Knotweed
C Licorice
C Magnesium
C Melatonin
C Nattokinase
C Phosphatidylcholine
C Phosphatidylserine
C Punicic Acid
C Royal Jelly
C Salvia hispanica
C Sea Buckthorn
C Theaflavins
C Vanadium
C Vitamin C
C Vitamin K
D Eclipta alba
D Coconut Oil
D Emblica officinalis
D Tetradecyl Thioacetic Acid
D Yerba mate
D Horse Chestnut
D Perilla Oil
D Pueraria lobata
D Pyrroloquinoline quinone
D Rubus coreanus
D Safflower Oil


  1. Seedat S, Stein DJ Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: an open trial . Int Clin Psychopharmacol. (1999)
  2. Colazingari S, et al The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial . Arch Gynecol Obstet. (2013)
  3. Minozzi M, Nordio M, Pajalich R The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients . Eur Rev Med Pharmacol Sci. (2013)
  4. Agostini R, Rossi F, Pajalich R Myoinositol/folic acid combination for the treatment of erectile dysfunction in type 2 diabetes men: a double-blind, randomized, placebo-controlled study . Eur Rev Med Pharmacol Sci. (2006)
  5. Fernandez ML Dietary cholesterol provided by eggs and plasma lipoproteins in healthy populations . Curr Opin Clin Nutr Metab Care. (2006)
  6. Djoussé L, et al Egg consumption and risk of type 2 diabetes in older adults . Am J Clin Nutr. (2010)
  7. Flynn MA, et al Serum lipids and eggs . J Am Diet Assoc. (1986)
  8. Bowman MP, et al Effect of dietary fat and cholesterol on plasma lipids and lipoprotein fractions in normolipidemic men . J Nutr. (1988)
  9. Chenoweth W, et al Influence of dietary cholesterol and fat on serum lipids in men . J Nutr. (1981)
  10. Effect of dietary eggs and ascorbic acid on plasma lipid and lipoprotein cholesterol levels in healthy young men
  11. Egg intake does not change plasma lipoprotein and coagulation profiles
  12. Johnson C, Greenland P Effects of exercise, dietary cholesterol, and dietary fat on blood lipids . Arch Intern Med. (1990)
  13. Sacks FM, et al Ingestion of egg raises plasma low density lipoproteins in free-living subjects . Lancet. (1984)
  14. Down-regulation of the low-density lipoprotein receptor by dietary cholesterol
  15. A double-blind, randomized, controlled trial of the effects of two eggs per day in moderately hypercholesterolemic and combined hyperlipidemic subjects taught the NCEP step I diet
  16. Romano G, et al Effects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients . Diabetologia. (1998)
  17. Mayurasakorn K, et al High-density lipoprotein cholesterol changes after continuous egg consumption in healthy adults . J Med Assoc Thai. (2008)
  18. Vishwanathan R, et al Consumption of 2 and 4 egg yolks/d for 5 wk increases macular pigment concentrations in older adults with low macular pigment taking cholesterol-lowering statins . Am J Clin Nutr. (2009)
  19. Katz DL, et al Egg consumption and endothelial function: a randomized controlled crossover trial . Int J Cardiol. (2005)
  20. Njike V, et al Daily egg consumption in hyperlipidemic adults--effects on endothelial function and cardiovascular risk . Nutr J. (2010)
  21. Jones PJ Dietary cholesterol and the risk of cardiovascular disease in patients: a review of the Harvard Egg Study and other data . Int J Clin Pract Suppl. (2009)
  22. Dietary cholesterol from eggs increases the ratio of total cholesterol to high-density lipoprotein cholesterol in humans: a meta-analysis
  23. Fernandez ML Effects of eggs on plasma lipoproteins in healthy populations . Food Funct. (2010)
  24. McNamara DJ The impact of egg limitations on coronary heart disease risk: do the numbers add up . J Am Coll Nutr. (2000)
  25. Fernandez ML, Calle M Revisiting dietary cholesterol recommendations: does the evidence support a limit of 300 mg/d . Curr Atheroscler Rep. (2010)
  26. Eggs, serum cholesterol, and coronary heart disease
  27. Hu FB, et al A prospective study of egg consumption and risk of cardiovascular disease in men and women . JAMA. (1999)
  28. Spence JD, Jenkins DJ, Davignon J Dietary cholesterol and egg yolks: not for patients at risk of vascular disease . Can J Cardiol. (2010)
  29. Herron KL, et al High intake of cholesterol results in less atherogenic low-density lipoprotein particles in men and women independent of response classification . Metabolism. (2004)
  30. Pearce KL, Clifton PM, Noakes M Egg consumption as part of an energy-restricted high-protein diet improves blood lipid and blood glucose profiles in individuals with type 2 diabetes . Br J Nutr. (2011)
  31. Goodrow EF, et al Consumption of one egg per day increases serum lutein and zeaxanthin concentrations in older adults without altering serum lipid and lipoprotein cholesterol concentrations . J Nutr. (2006)
  32. Effect of a High Saturated Fat and No-Starch Diet on Serum Lipid Subfractions in Patients With Documented Atherosclerotic Cardiovascular Disease
  33. Mutungi G, et al Dietary cholesterol from eggs increases plasma HDL cholesterol in overweight men consuming a carbohydrate-restricted diet . J Nutr. (2008)
  34. Mutungi G, et al Eggs distinctly modulate plasma carotenoid and lipoprotein subclasses in adult men following a carbohydrate-restricted diet . J Nutr Biochem. (2010)
  35. Fernández-Robredo P, et al Egg yolk improves lipid profile, lipid peroxidation and retinal abnormalities in a murine model of genetic hypercholesterolemia . J Nutr Biochem. (2008)
  36. Benjamin J, et al Acute inositol does not attenuate m-CPP-induced anxiety, mydriasis and endocrine effects in panic disorder . J Psychiatr Res. (1997)
  37. Palatnik A, et al Double-blind, controlled, crossover trial of inositol versus fluvoxamine for the treatment of panic disorder . J Clin Psychopharmacol. (2001)
  38. Benjamin J, et al Double-blind, placebo-controlled, crossover trial of inositol treatment for panic disorder . Am J Psychiatry. (1995)
  39. Fux M, et al Inositol treatment of obsessive-compulsive disorder . Am J Psychiatry. (1996)
  40. Chengappa KN, et al Inositol as an add-on treatment for bipolar depression . Bipolar Disord. (2000)
  41. Nierenberg AA, et al Treatment-resistant bipolar depression: a STEP-BD equipoise randomized effectiveness trial of antidepressant augmentation with lamotrigine, inositol, or risperidone . Am J Psychiatry. (2006)
  42. Levine J, et al Double-blind, controlled trial of inositol treatment of depression . Am J Psychiatry. (1995)
  43. Nordio M, Proietti E The combined therapy with myo-inositol and D-chiro-inositol reduces the risk of metabolic disease in PCOS overweight patients compared to myo-inositol supplementation alone . Eur Rev Med Pharmacol Sci. (2012)
  44. Donà G, et al Inositol administration reduces oxidative stress in erythrocytes of patients with polycystic ovary syndrome . Eur J Endocrinol. (2012)
  45. Gerli S, Mignosa M, Di Renzo GC Effects of inositol on ovarian function and metabolic factors in women with PCOS: a randomized double blind placebo-controlled trial . Eur Rev Med Pharmacol Sci. (2003)
  46. Raffone E, Rizzo P, Benedetto V Insulin sensitiser agents alone and in co-treatment with r-FSH for ovulation induction in PCOS women . Gynecol Endocrinol. (2010)
  47. Costantino D, et al Metabolic and hormonal effects of myo-inositol in women with polycystic ovary syndrome: a double-blind trial . Eur Rev Med Pharmacol Sci. (2009)
  48. Genazzani AD, et al Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients . Gynecol Endocrinol. (2012)
  49. Lisi F, et al Pretreatment with myo-inositol in non polycystic ovary syndrome patients undergoing multiple follicular stimulation for IVF: a pilot study . Reprod Biol Endocrinol. (2012)
  50. Genazzani AD, et al Myo-inositol administration positively affects hyperinsulinemia and hormonal parameters in overweight patients with polycystic ovary syndrome . Gynecol Endocrinol. (2008)
  51. Papaleo E, et al Myo-inositol in patients with polycystic ovary syndrome: a novel method for ovulation induction . Gynecol Endocrinol. (2007)
  52. Gerli S, et al Randomized, double blind placebo-controlled trial: effects of myo-inositol on ovarian function and metabolic factors in women with PCOS . Eur Rev Med Pharmacol Sci. (2007)
  53. D'Anna R, et al Myo-inositol may prevent gestational diabetes in PCOS women . Gynecol Endocrinol. (2012)
  54. Corrado F, et al The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes . Diabet Med. (2011)
  55. Ciotta L, et al Effects of myo-inositol supplementation on oocyte's quality in PCOS patients: a double blind trial . Eur Rev Med Pharmacol Sci. (2011)
  56. Zacchè MM, et al Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome . Gynecol Endocrinol. (2009)
  57. Santamaria A, et al One-year effects of myo-inositol supplementation in postmenopausal women with metabolic syndrome . Climacteric. (2012)
  58. Unfer V, et al Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial . Eur Rev Med Pharmacol Sci. (2011)
  59. Minozzi M, D'Andrea G, Unfer V Treatment of hirsutism with myo-inositol: a prospective clinical study . Reprod Biomed Online. (2008)
  60. Iuorno MJ, et al Effects of d-chiro-inositol in lean women with the polycystic ovary syndrome . Endocr Pract. (2002)
  61. Gianfranco C, et al Myo-inositol in the treatment of premenstrual dysphoric disorder . Hum Psychopharmacol. (2011)
  62. Salloway S, et al A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease . Neurology. (2011)
  63. Maeba R, et al Myo-inositol treatment increases serum plasmalogens and decreases small dense LDL, particularly in hyperlipidemic subjects with metabolic syndrome . J Nutr Sci Vitaminol (Tokyo). (2008)
  64. Papaleo E, et al Myo-inositol may improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial . Fertil Steril. (2009)
  65. Lam S, et al A phase I study of myo-inositol for lung cancer chemoprevention . Cancer Epidemiol Biomarkers Prev. (2006)
  66. Levine J, et al Lack of effect of inositol treatment in chronic schizophrenia . Biol Psychiatry. (1993)
  67. Levine J, et al Lack of effect of 6 g inositol treatment of post-ECT cognitive function in humans . J Psychiatr Res. (1995)
  68. Nemets B, et al Inositol addition does not improve depression in SSRI treatment failures . J Neural Transm. (1999)
  69. Levine J, et al CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia . Eur Neuropsychopharmacol. (1994)
  70. Gelber D, Levine J, Belmaker RH Effect of inositol on bulimia nervosa and binge eating . Int J Eat Disord. (2001)
  71. Nemets B, et al Myo-inositol has no beneficial effect on premenstrual dysphoric disorder . World J Biol Psychiatry. (2002)
  72. Levine J, et al Inositol treatment of autism . J Neural Transm. (1997)
  73. Kaplan Z, et al Inositol treatment of post-traumatic stress disorder . Anxiety. (1996)
  74. Barak Y, et al Inositol treatment of Alzheimer's disease: a double blind, cross-over placebo controlled trial . Prog Neuropsychopharmacol Biol Psychiatry. (1996)
  75. Allan SJ, et al The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial . Br J Dermatol. (2004)

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