Insulin Sensitivity

A relation of how well Insulin in the body is able to affect cells by inducing insulin-like effects. Insulin resistance is poor efficacy in affecting cells, and insulin sensitivity is good efficacy. Chronic Insulin resistance is one of the pathological signs of type II diabetes.

This page features 44 unique references to scientific papers.

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Insulin Sensitivity is a function of how well your body can handle glucose (blood sugar) through insulin secretion. Insulin is secreted from an organ called the pancreas in response to elevating blood sugar, and the less insulin that is needed to get the job done is how sensitive you are to insulin.

For a somewhat full review of insulin sensitivity, please refer to our FAQ page on increasing insulin sensitivity.

In general, being more insulin sensitive is better. If you had to blindly choose between being insulin sensitive or resistant, sensitive is probably the way to go.

Keep in mind that there are times where insulin resistance is good. The third trimester of pregnancy is one where insulin resistance is good as by hindering the ability of the mother to get glucose the baby gets more (up until a point, gestational diabetes is not that good) and fat loss diets and supplements tend to induce transient states of insulin resistance; the latter is not wholly bad because you should be having less food anyways and thus there really isn't any drastic spike in blood glucose to be resistant to on a fat loss diet (if you are doing it right).

Kurtis Frank

Insulin , sensitivity , resistance

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Insulin Sensitivity
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Chromium
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
A Conjugated Linoleic Acid
A Fish Oil
B Caffeine
B Cocoa Extract
B Green Tea Catechins
B Inositol
B L-Carnitine
B Magnesium
B Vitamin B3
B Nicotine
B Panax ginseng
C Gynostemma pentaphyllum
C Tauroursodeoxycholic Acid
C Arginine
C Bladderwrack
C Blueberry
C Curcumin
C Fenugreek
C Grapefruit
C Melatonin
C Olive leaf extract
C Red Clover Extract
C Resveratrol
C Sodium Bicarbonate
C Spirulina
C Vitamin D
C Vitamin K
C Whey Protein
C Yacon
C Zinc
C Alpha-Lipoic Acid
C Berberine
C Creatine
C Dehydroepiandrosterone
C Garlic
C Hesperidin
C Japanese Knotweed
C Licorice
C Nitrate
C Psyllium
C Punicic Acid
C Rose Hip
C Royal Jelly
C Stinging Nettle
C Vanadium
C Vitamin C
C Vitamin E
D Coconut Oil
D Coffee
D Mangifera indica
D Safflower Oil
D Tetradecyl Thioacetic Acid


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  2. Colazingari S, et al The combined therapy myo-inositol plus D-chiro-inositol, rather than D-chiro-inositol, is able to improve IVF outcomes: results from a randomized controlled trial . Arch Gynecol Obstet. (2013)
  3. Minozzi M, Nordio M, Pajalich R The Combined therapy myo-inositol plus D-Chiro-inositol, in a physiological ratio, reduces the cardiovascular risk by improving the lipid profile in PCOS patients . Eur Rev Med Pharmacol Sci. (2013)
  4. Agostini R, Rossi F, Pajalich R Myoinositol/folic acid combination for the treatment of erectile dysfunction in type 2 diabetes men: a double-blind, randomized, placebo-controlled study . Eur Rev Med Pharmacol Sci. (2006)
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  22. D'Anna R, et al Myo-inositol may prevent gestational diabetes in PCOS women . Gynecol Endocrinol. (2012)
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  25. Zacchè MM, et al Efficacy of myo-inositol in the treatment of cutaneous disorders in young women with polycystic ovary syndrome . Gynecol Endocrinol. (2009)
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  27. Unfer V, et al Myo-inositol rather than D-chiro-inositol is able to improve oocyte quality in intracytoplasmic sperm injection cycles. A prospective, controlled, randomized trial . Eur Rev Med Pharmacol Sci. (2011)
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  34. Lam S, et al A phase I study of myo-inositol for lung cancer chemoprevention . Cancer Epidemiol Biomarkers Prev. (2006)
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  44. Allan SJ, et al The effect of inositol supplements on the psoriasis of patients taking lithium: a randomized, placebo-controlled trial . Br J Dermatol. (2004)

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