Hydration is an approximately measurement of reserves of water on the human body, and a severe reduction in hydration from either no water intake or diuretic usage is known as dehydration. Some supplements are either diuretic or may promote water retention.

This page features 4 unique references to scientific papers.

MUST GET: Supplement Stack Guides - Saving You Money & Time

The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Hydration
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Creatine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Alanylglutamine
C Quercetin
C Sodium Bicarbonate
C Trimethylglycine
D Rooibos


  1. Hoffman JR1, et al L-alanyl-L-glutamine ingestion maintains performance during a competitive basketball game . J Int Soc Sports Nutr. (2012)
  2. Hoffman JR1, et al Examination of the efficacy of acute L-alanyl-L-glutamine ingestion during hydration stress in endurance exercise . J Int Soc Sports Nutr. (2010)
  3. Leite RD1, et al Improvement of intestinal permeability with alanyl-glutamine in HIV patients: a randomized, double blinded, placebo-controlled clinical trial . Arq Gastroenterol. (2013)
  4. Harris RC1, et al L-glutamine absorption is enhanced after ingestion of L-alanylglutamine compared with the free amino acid or wheat protein . Nutr Res. (2012)

(Users who contributed to this page include )