Hydration is an approximately measurement of reserves of water on the human body, and a severe reduction in hydration from either no water intake or diuretic usage is known as dehydration. Some supplements are either diuretic or may promote water retention.

This page features 12 unique references to scientific papers.

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The Human Effect Matrix looks at human studies (excluding animal/petri-dish studies) to tell you what supplements affect Hydration
Grade Level of Evidence
A Robust research conducted with repeated double blind clinical trials
B Multiple studies where at least two are double-blind and placebo controlled
C Single double blind study or multiple cohort studies
D Uncontrolled or observational studies only
Level of Evidence
Magnitude of Effect Size
Scientific Consensus Comments
A Creatine
Comparative Health Goals evidence only available to buyers of our Supplement-Goals Reference

All information is still available and viewable on their respective supplement page.
C Alanylglutamine
C Quercetin
C Sodium Bicarbonate
C Trimethylglycine
D Rooibos


  1. Dietary anti-oxidant supplementation combined with Quercetin improves cycling time trial performance
  2. MacRae HS, Mefferd KM Dietary antioxidant supplementation combined with quercetin improves cycling time trial performance . Int J Sport Nutr Exerc Metab. (2006)
  3. Cheuvront SN, et al No effect of nutritional adenosine receptor antagonists on exercise performance in the heat . Am J Physiol Regul Integr Comp Physiol. (2009)
  4. Talirevic E, Jelena S Quercetin in the treatment of dyslipidemia . Med Arh. (2012)
  5. Kuennen M, et al Thermotolerance and heat acclimation may share a common mechanism in humans . Am J Physiol Regul Integr Comp Physiol. (2011)
  6. Knab AM, et al Quercetin with vitamin C and niacin does not affect body mass or composition . Appl Physiol Nutr Metab. (2011)
  7. Knab AM, et al Influence of quercetin supplementation on disease risk factors in community-dwelling adults . J Am Diet Assoc. (2011)
  8. Boots AW, et al Quercetin reduces markers of oxidative stress and inflammation in sarcoidosis . Clin Nutr. (2011)
  9. Egert S, Rimbach G, Müller MJ No evidence for a thermic effect of the dietary flavonol quercetin: a pilot study in healthy normal-weight women . Eur J Appl Physiol. (2011)
  10. Bigelman KA, et al Effects of 6 weeks of quercetin supplementation on energy, fatigue, and sleep in ROTC cadets . Mil Med. (2011)
  11. Konrad M, et al The acute effect of ingesting a quercetin-based supplement on exercise-induced inflammation and immune changes in runners . Int J Sport Nutr Exerc Metab. (2011)
  12. Abbey EL, Rankin JW Effect of quercetin supplementation on repeated-sprint performance, xanthine oxidase activity, and inflammation . Int J Sport Nutr Exerc Metab. (2011)

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